alpha-(4-Bromophenyl)pyridine-2-acetonitrile

Base Information

Chemical Name:alpha-(4-Bromophenyl)pyridine-2-acetonitrile
CAS No.:85750-24-9
Molecular Formula:C13H9 Br N2
Molecular Weight:273.132
Hs Code.:
European Community (EC) Number:288-551-5
DSSTox Substance ID:DTXSID001006362
Nikkaji Number:J310.865A
Mol file:85750-24-9.mol

Synonyms:85750-24-9;alpha-(4-Bromophenyl)pyridine-2-acetonitrile;2-(4-bromophenyl)-2-pyridin-2-ylacetonitrile;2-(4-BROMOPHENYL)-2-(PYRIDIN-2-YL)ACETONITRILE;EINECS 288-551-5;2-Pyridineacetonitrile,a-(4-bromophenyl)-;alpha-(4-Bromophenyl)-2-pyridineacetonitrile;a-(4-Bromophenyl)-2-pyridineacetonitrile;starbld0006749;DTXSID001006362;AKOS022507516;(4-Bromophenyl)(pyridin-2-yl)acetonitrile;NS00064600;alpha -(4-Bromophenyl)-2-pyridineacetonitrile

Suppliers and Price of alpha-(4-Bromophenyl)pyridine-2-acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
α-(4-Bromophenyl)-2-pyridineacetonitrile
500mg
$ 150.00

Total 10 raw suppliers

Chemical Property of alpha-(4-Bromophenyl)pyridine-2-acetonitrile

Chemical Property:

Boiling Point:385.8oC at 760 mmHg
Flash Point:187.1oC
PSA：36.68000
Density:1.446g/cm3
LogP:3.49958
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly),Ethyl Acetate (Slightly)
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:271.99491
Heavy Atom Count:16
Complexity:262

Purity/Quality:

99% ^*data from raw suppliers

α-(4-Bromophenyl)-2-pyridineacetonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(C#N)C2=CC=C(C=C2)Br
Uses α-(4-Bromophenyl)-2-pyridineacetonitrile, is an intermediate in the synthesis of Bromopheniramine Maleate, a derivative of Pheniramine (P297200), used to treat allergic conditions such as hay fever or urticaria.

Technology Process of alpha-(4-Bromophenyl)pyridine-2-acetonitrile

There total 1 articles about alpha-(4-Bromophenyl)pyridine-2-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 109-09-1
2-chloropyridine

: 16532-79-9
4-Bromophenylacetonitrile

: 85750-24-9
(4-Bromo-phenyl)-pyridin-2-yl-acetonitrile

Guidance literature:: With sodium amide; In toluene;
DOI:10.1002/ardp.19893220310

Reference yield: 68.0%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 85750-24-9
(4-Bromo-phenyl)-pyridin-2-yl-acetonitrile

: 122376-82-3
2-(4-Bromo-phenyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-pyridin-2-yl-butyronitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; 1.) r.t., 1 h, 2.) 140 deg C, 5 h;
DOI:10.1002/ardp.19893220310

Reference yield:

: 85750-24-9
(4-Bromo-phenyl)-pyridin-2-yl-acetonitrile

: 4-(4-Bromo-phenyl)-N-[2-(1H-imidazol-4-yl)-ethyl]-4-pyridin-2-yl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: Triton B / methanol; dioxane

2: 70percent H₂SO₄ / 5 h / 120 °C

3: 1) N,N'-carbonyldiimidazole / 1) THF, 30 min, 2) THF, overnight

With sulfuric acid; N-benzyl-trimethylammonium hydroxide; 1,1'-carbonyldiimidazole; In 1,4-dioxane; methanol;
DOI:10.1002/ardp.19973301104