2-Chloropyridine

Base Information

• Chemical Name: 2-Chloropyridine
• CAS No.: 109-09-1
• Molecular Formula: C5H4ClN
• Molecular Weight: 113.546
• Hs Code.: 29333999
• European Community (EC) Number: 203-646-3
• NSC Number: 4649
• UN Number: 2822
• UNII: 8HMD45AYEJ
• DSSTox Substance ID: DTXSID8024810
• Nikkaji Number: J2.430I
• Wikipedia: 2-Chloropyridine
• Wikidata: Q209364
• Metabolomics Workbench ID: 56184
• ChEMBL ID: CHEMBL509579
• Mol file: 109-09-1.mol

Synonyms:2-chloropyridine

Chemical Property of 2-Chloropyridine

Chemical Property:

• Appearance/Colour: clear colourless to light yellow liquid
• Vapor Pressure: 1.7 mm Hg ( 20 °C)
• Melting Point: -46 °C
• Refractive Index: n20/D 1.532(lit.)
• Boiling Point: 170 °C at 760 mmHg
• PKA: 0.49(at 25℃)
• Flash Point: 65 °C
• PSA: 12.89000
• Density: 1.2 g/cm³
• LogP: 1.73500
• Storage Temp.: Refrigerator
• Solubility.: 27g/l
• Water Solubility.: 27 g/L (20 ºC)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 113.0032268
• Heavy Atom Count: 7
• Complexity: 56
• Transport DOT Label: Poison

Purity/Quality:

99% ^*data from raw suppliers

2-Chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36/37/39-45-28A-27

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C1=CC=NC(=C1)Cl
• Uses: 2-Chloropyridine (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during t he decomposition of specific insecticides. 2- Chloropyridine is used as an intermediate chemical in the production of various pyrithione, for use in cosmetics, personal care products and pharmaceutical products.

Technology Process of 2-Chloropyridine

There total 116 articles about 2-Chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloropyridine-N-oxide (2402-95-1) → 2-chloropyridine (109-09-1)

Guidance literature:

With cerium(III) chloride heptahydrate; zinc; In methanol; at 20 ℃; for 0.5h;

DOI:10.5012/bkcs.2013.34.2.359

Reference yield: 92.0%

2-bromo-pyridine (109-04-6) → 2-chloropyridine (109-09-1)

Guidance literature:

With trans-bis(glycinato)copper(II) monohydrate; tetramethlyammonium chloride; In ethanol; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.apcata.2013.12.022

Reference yield: 80.0%

C19H14N2O2 (93845-11-5) → 2-chloropyridine (109-09-1) + benzophenone (119-61-9) + hexachloroethane (67-72-1) + benzophenone azine (983-79-9)

Guidance literature:

With tetrachloromethane; Yields of byproduct given; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(00)82327-8

upstream raw materials:

pyridine

2-Pyridone

2-aminopyridine

2-hydroxypyridin

Downstream raw materials:

[1,2']bipyridylium; picrate

di(pyridin-2-yl)amine

Chlorothen

2-Cyanopyridine

Refernces

• 1、 Jung,Jung,Park. "Preparation of 2-chloropyridine". . p. 2507 - 2511. Retrieved 2001.
• 2、 Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua. "Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis". . p. 146 - 153. Retrieved 2020.
• 3、 Pu, Yu-Ming,Christesen, Alan,Ku, Yi-Yin. "A simple and highly effective oxidative chlorination protocol for the preparation of arenesulfonyl chlorides". . p. 418 - 421. Retrieved 2010.
• 4、 Fiorio, Jhonatan L.,Rossi, Liane M.. "Clean protocol for deoxygenation of epoxides to alkenes: Via catalytic hydrogenation using gold". . p. 312 - 318. Retrieved 2021/01/29.
• 5、 Zhang, Xitao,Feng, Xiujuan,Zhang, Haixia,Yamamoto, Yoshinori,Bao, Ming. "Transition-metal-free decarboxylative halogenation of 2-picolinic acids with dihalomethane under oxygen conditions". supporting information. p. 5565 - 5570. Retrieved 2019/10/22.