N-[2-(1-Hydroxycyclohexyl)phenyl]formamide

Base Information

Chemical Name:N-[2-(1-Hydroxycyclohexyl)phenyl]formamide
CAS No.:82757-20-8
Molecular Formula:C13H17NO2
Molecular Weight:219.283
Hs Code.:
DSSTox Substance ID:DTXSID40509385
Wikidata:Q82366904

Synonyms:N-[2-(1-Hydroxycyclohexyl)phenyl]formamide;82757-20-8;DTXSID40509385

Suppliers and Price of N-[2-(1-Hydroxycyclohexyl)phenyl]formamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-[2-(1-Hydroxycyclohexyl)phenyl]formamide

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:219.125928785
Heavy Atom Count:16
Complexity:236

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)(C2=CC=CC=C2NC=O)O

Technology Process of N-[2-(1-Hydroxycyclohexyl)phenyl]formamide

There total 4 articles about N-[2-(1-Hydroxycyclohexyl)phenyl]formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 10113-39-0
N-formyl-2-iodoaniline

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 82757-20-8
N-[2-(1-hydroxycyclohexyl)phenyl]formamide

Guidance literature:: N-formyl-2-iodoaniline; With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

cyclohexanone; In tetrahydrofuran; hexane; at -78 ℃; for 3h;
DOI:10.1016/j.tet.2006.10.030

Reference yield: 56.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: ortho-lithiophenyllithioformamide

: 82757-20-8
N-[2-(1-hydroxycyclohexyl)phenyl]formamide

Guidance literature:: In tetrahydrofuran; at -105 ℃;
DOI:10.1016/S0040-4039(00)87259-7

Reference yield:

: 10113-38-9
N-(2-bromophenyl)formamide

: 82757-20-8
N-[2-(1-hydroxycyclohexyl)phenyl]formamide

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyl lithium / hexane; tetrahydrofuran / -100 °C

2: 56 percent / tetrahydrofuran / -105 °C

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4039(00)87259-7