1-(2-Aminophenyl)cyclohexan-1-ol

Base Information

• Chemical Name: 1-(2-Aminophenyl)cyclohexan-1-ol
• CAS No.: 106795-52-2
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• DSSTox Substance ID: DTXSID20543686
• Wikidata: Q82420627
• Mol file: 106795-52-2.mol

Synonyms:106795-52-2;1-(2-aminophenyl)cyclohexan-1-ol;2-Aminophenylcyclohexanol;1-(2-aminophenyl)cyclohexanol;SCHEMBL632646;1-(2-amino-phenyl)-cyclohexanol;DTXSID20543686;YDYYIWCXMILREQ-UHFFFAOYSA-N;SB84887

Chemical Property of 1-(2-Aminophenyl)cyclohexan-1-ol

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)(C2=CC=CC=C2N)O

Technology Process of 1-(2-Aminophenyl)cyclohexan-1-ol

There total 7 articles about 1-(2-Aminophenyl)cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-[2-(1-hydroxycyclohexyl)phenyl]formamide (82757-20-8) → 1-(2-aminophenyl)cyclohexan-1-ol (106795-52-2)

Guidance literature:

With potassium hydroxide; In methanol; for 1.5h; Heating;

Reference yield: 49.0%

1-(2-nitro-phenyl)-cyclohexanol (861842-15-1) → 1-(2-aminophenyl)cyclohexan-1-ol (106795-52-2)

Guidance literature:

With hydrogen; nickel; In ethanol; at 20 ℃; for 4h; under 2250.23 Torr;

Reference yield: 45.0%

1,5-dibromo-pentane (111-24-0) + 2-carbomethoxyaniline (134-20-3) → 1-(2-aminophenyl)cyclohexan-1-ol (106795-52-2)

Guidance literature:

1,5-dibromo-pentane; With magnesium; In diethyl ether; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique; Glovebox;

2-carbomethoxyaniline; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1002/chem.201804777

upstream raw materials:

isatoic anhydride

pentamethylenebis(magnesium bromide)

N-[2-(1-hydroxycyclohexyl)phenyl]formamide

1,5-dibromo-pentane

Downstream raw materials:

2‘,3‘,4‘,5‘-tetrahydro-[1,1‘-biphenyl]-2-amine

N-[2-(cyclohex-1-enyl)phenyl]acetamide

2-methylspiro<4H-3,1-benzoxazine-4,1'-cyclohexane>