2-PyridinaMine,5-pyrazinyl

Base Information

• Chemical Name: 2-PyridinaMine,5-pyrazinyl
• CAS No.: 827588-90-9
• Molecular Formula: C9H8N4
• Molecular Weight: 172.189
• Mol file: 827588-90-9.mol

Synonyms:2-Pyridinamine,5-pyrazinyl;

Chemical Property of 2-PyridinaMine,5-pyrazinyl

Chemical Property:

• PSA: 65.42000
• LogP: 1.05090

Purity/Quality:

97% ^*data from raw suppliers

5-(pyrazin-2-yl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PyridinaMine,5-pyrazinyl

There total 7 articles about 2-PyridinaMine,5-pyrazinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-aminopyridine-5-boronic acid pinacol ester (827614-64-2) + 2-iodopyrazine (32111-21-0) → 2-(6-amino-pyridin-3-yl)pyrazine (827588-90-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 90 ℃; for 10h; Sealed tube; Inert atmosphere;

DOI:10.1021/acsmedchemlett.6b00038

Reference yield:

2-(6-nitro-pyridin-3-yl)pyrazine → 2-(6-amino-pyridin-3-yl)pyrazine (827588-90-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃;

Reference yield:

2-aminopyridine-5-boronic acid pinacol ester (827614-64-2) + 2-chloropyrazin (14508-49-7) → 2-(6-amino-pyridin-3-yl)pyrazine (827588-90-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.11.026

upstream raw materials:

2-aminopyridine-5-boronic acid pinacol ester

2-iodopyrazine

5-bromo-2-pyridylamine

2-chloropyrazin

Downstream raw materials:

2-(4-(2-(difluoromethyl)pyridin-4-yl)phenyl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

2-(3-cyano-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

2-(3-fluoro-4-(2-fluoropyridin-4-yl)phenyl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

2-(4-bromo-3-(trifluoromethyl)phenyl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

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