Synonyms:2-amino-5-bromopyridine
98.00% *data from raw suppliers
2-Amino-5-bromopyridine *data from reagent suppliers
Xn,
Xi
There total 28 articles about 2-Amino-5-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 98.0%
Reference yield: 96.0%
Reference yield: 90.0%
This research presents the synthesis and anticonvulsant evaluation of new 6-bromoimidazo[1,2-a]pyridine-2-carbohydrazide derivatives, which are designed to possess biologically active hydrazone functionality and substituted 1,2,4-triazole moieties. The purpose of the study was to develop novel antiepileptic drugs with improved therapeutic actions and reduced toxicity. The synthesis involved various chemicals such as 5-bromo-2-aminopyridine, ethyl bromopyruvate, hydrazine hydrate, aromatic aldehydes, carbon disulfide, potassium hydroxide, and different alkyl/benzyl halides. The structures of the synthesized compounds were confirmed through spectral techniques like FTIR, 1H NMR, 13C NMR, and mass spectrometry. The in vivo anticonvulsant properties were assessed using maximal electroshock seizure and subcutaneous pentylene tetrazole methods, with toxicity studies performed using the rotarod method. The research concluded that most of the new compounds exhibited significant anticonvulsant properties without toxicity up to 100 mg/kg, with compounds 3b and 4 showing complete protection against seizures, comparable to the standard drug diazepam. These findings suggest that linking imidazo[1,2-a]pyridines with triazole and hydrazone moieties can lead to potent anticonvulsants with minimal side effects.
The research focuses on the synthesis and evaluation of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydroimidazo[1,2-a]pyridines for their antiprotozoal activity and DNA binding affinity. The key dinitrile intermediates 4a–d were synthesized by reacting phenacyl bromide 1 with appropriate 2-amino-5-bromopyridines to yield 3a–d, followed by Suzuki coupling with 4-cyanophenylboronic acid. The bis-amidoximes 5a–d were then converted to the bis-O-acetoxyamidoximes and further catalytically hydrogenated to yield the acetate salts of 2,6-bis[4-(amidinophenyl)]-imidazo[1,2-a]pyridines 7a–d and the saturated analogue 2,6-bis[4-(amidinophenyl)]-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine 8. The N-methoxyamidines 6a–d were prepared as potential prodrugs. These compounds exhibited strong DNA binding affinity and were very active in vitro against Trypanosoma brucei rhodesiense (T. b. r.), with IC50 values between 7 and 38 nM, but less effective against Plasmodium falciparum (P. f.), with IC50 values between 23 and 92 nM. In the T. b. r. STIB900 mouse model, compounds 7c and 7d showed slightly higher activity than furamidine, while only one prodrug 6b exhibited moderate activity. The research highlights the potential of these compounds as antiprotozoal agents and demonstrates the importance of the choice of linker and solvent in the synthesis and activity of these compounds.
What can I do for you?
Get Best Price
Total 8 Pictures about this product
