1-(5-broMopyridin-2-yl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-(5-broMopyridin-2-yl)cyclopropanecarboxylic acid
• CAS No.: 827628-42-2
• Molecular Formula: C9H8BrNO2
• Molecular Weight: 242.06900
• Hs Code.: 2933399090
• Mol file: 827628-42-2.mol

Synonyms:

Chemical Property of 1-(5-broMopyridin-2-yl)cyclopropanecarboxylic acid

Chemical Property:

• PSA: 50.19000
• LogP: 1.96030

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Bromopyridin-2-yl)cyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-broMopyridin-2-yl)cyclopropanecarboxylic acid

There total 3 articles about 1-(5-broMopyridin-2-yl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-(5-bromopyridin-2-yl)cyclopropane-1-carbonitrile (827628-15-9) → 1-(5-bromopyridin-2-yl)cyclopropanecarboxylic acid (827628-42-2)

Guidance literature:

1-(5-bromopyridin-2-yl)cyclopropane-1-carbonitrile; With water; sodium hydroxide; In ethanol; at 100 ℃; for 14h;

With hydrogenchloride; sodium dihydrogenphosphate; In ethanol; pH=4; Cooling with ice;

Reference yield:

5-bromo-2-fluoropyridine (766-11-0) → 1-(5-bromopyridin-2-yl)cyclopropanecarboxylic acid (827628-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hexamethylsilazane / toluene / 0.08 h / Cooling with ice

2.1: sodium hydroxide; water / ethanol / 14 h / 100 °C

2.2: pH 4 / Cooling with ice

With water; potassium hexamethylsilazane; sodium hydroxide; In ethanol; toluene;

Reference yield:

2-(5-bromopyridin-2-yl)acetonitrile (312325-72-7) → 1-(5-bromopyridin-2-yl)cyclopropanecarboxylic acid (827628-42-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; benzyltri(n-butyl)ammonium chloride / acetonitrile; water / 4 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 14 h / 100 °C

2.2: pH 4 / Cooling with ice

With water; benzyltri(n-butyl)ammonium chloride; sodium hydroxide; In ethanol; water; acetonitrile;

upstream raw materials:

5-bromo-2-fluoropyridine

2-(5-bromopyridin-2-yl)acetonitrile

1-(5-bromopyridin-2-yl)cyclopropane-1-carbonitrile

Downstream raw materials:

(1-(5-bromopyridin-2-yl)cyclopropyl)methanol

Refernces

• 1、 -. "BTK INHIBITORS". . . Retrieved 2016/08/03.