5-Bromo-2-fluoropyridine

Base Information

Chemical Name:5-Bromo-2-fluoropyridine
CAS No.:766-11-0
Molecular Formula:C5H3BrFN
Molecular Weight:175.988
Hs Code.:29339900
European Community (EC) Number:629-380-1
DSSTox Substance ID:DTXSID40382478
Nikkaji Number:J1.309.714C
Wikidata:Q72479466
Mol file:766-11-0.mol

Synonyms:2-fluoro-5-bromopyridine;5-bromo-2-fluoropyridine

Suppliers and Price of 5-Bromo-2-fluoropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Fluoro-5-bromopyridine
10g
$ 150.00

TCI Chemical
5-Bromo-2-fluoropyridine >98.0%(GC)
25g
$ 257.00

TCI Chemical
5-Bromo-2-fluoropyridine >98.0%(GC)
5g
$ 99.00

SynQuest Laboratories
5-Bromo-2-fluoropyridine 99%
10 g
$ 35.00

SynQuest Laboratories
5-Bromo-2-fluoropyridine 99%
25 g
$ 75.00

SynQuest Laboratories
5-Bromo-2-fluoropyridine 99%
100 g
$ 225.00

Sigma-Aldrich
5-Bromo-2-fluoropyridine 99%
5g
$ 118.00

Oakwood
5-Bromo-2-fluoropyridine 99%
100g
$ 100.00

Matrix Scientific
5-Bromo-2-fluoropyridine 98%
100g
$ 78.00

Matrix Scientific
5-Bromo-2-fluoropyridine 98%
25g
$ 24.00

Total 153 raw suppliers

Chemical Property of 5-Bromo-2-fluoropyridine

Chemical Property:

Appearance/Colour:clear colorless yellowish liquid
Vapor Pressure:1.37mmHg at 25°C
Refractive Index:n20/D 1.5325(lit.)
Boiling Point:178 °C at 760 mmHg
PKA:-2.79±0.10(Predicted)
Flash Point:61.4 °C
PSA：12.89000
Density:1.707 g/cm³
LogP:1.98320
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:174.94329
Heavy Atom Count:8
Complexity:78.8

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-bromopyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,Xn
Hazard Codes:Xi,Xn
Statements: 36/37/38-22
Safety Statements: 26-36/37-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC=C1Br)F
Uses 2-Fluoro-5-bromopyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. Also used in the synthesis of benzofurano[3,2-d]pyrimidin-2-one derived inhbitors.

Technology Process of 5-Bromo-2-fluoropyridine

There total 6 articles about 5-Bromo-2-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 403-45-2
6-fluoronicotinic acid

: 766-11-0
5-bromo-2-fluoropyridine

Guidance literature:: With bromine; mercury(II) oxide; In tetrachloromethane; hexane;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 766-11-0
5-bromo-2-fluoropyridine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 23 ℃; for 4h;
DOI:10.1021/ol047688v

Reference yield:

: 53939-30-3
5-bromo-2-chloropyridine

: 766-11-0
5-bromo-2-fluoropyridine

Guidance literature:: With p-methoxybenzoyl fluoride; 2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene; In N,N-dimethyl-formamide; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b00538