(DIETHOXYPHOSPHORYL)DIFLUOROMETHYLZINC BROMIDE

Base Information

• Chemical Name: (DIETHOXYPHOSPHORYL)DIFLUOROMETHYLZINC BROMIDE
• CAS No.: 82845-20-3
• Molecular Formula: C5H10BrF2O3PZn
• Molecular Weight: 332.397
• Hs Code.: 2931900090
• Mol file: 82845-20-3.mol

Synonyms:((diethoxyphosphinyl)difluoromethyl)zinc bromide;[(diethoxyphosphoryl)difluoromethyl]zinc bromide;Zinc,bromo[(diethoxyphosphinyl)difluoromethyl];(Diethoxyphosphoryl)difluoromethylzinc bromide 0.5M in Tetrahydrofuran;[(Diethylphosphinyl)difluoromethyl]zinc bromide;

Chemical Property of (DIETHOXYPHOSPHORYL)DIFLUOROMETHYLZINC BROMIDE

Chemical Property:

• PSA: 45.34000
• LogP: 3.61510

Purity/Quality:

97% ^*data from raw suppliers

(Diethoxyphosphoryl)difluoromethylzincbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (DIETHOXYPHOSPHORYL)DIFLUOROMETHYLZINC BROMIDE

There total 2 articles about (DIETHOXYPHOSPHORYL)DIFLUOROMETHYLZINC BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (bromodifluoromethyl)phosphonate (65094-22-6) → [(diethoxyphosphoryl)difluoromethyl]zinc bromide (82845-20-3)

Guidance literature:

With zinc; In N,N-dimethyl acetamide; at 20 - 45 ℃; for 3h;

Reference yield:

diethyl (bromodifluoromethyl)phosphonate (65094-22-6) → Diethyl difluoromethylphosphonate (1478-53-1) + [(diethoxyphosphoryl)difluoromethyl]zinc bromide (82845-20-3)

Guidance literature:

With zinc; In 1,2-dimethoxyethane; for 48h; Ambient temperature;

DOI:10.1080/10426509708043514

Reference yield: 90.0%

N-(benzyloxycarbonyl)-L-aspartic acid-4-chloride-1-benzyl ester (64578-11-6) + [(diethoxyphosphoryl)difluoromethyl]zinc bromide (82845-20-3) → (S)-2-Benzyloxycarbonylamino-5-(diethoxy-phosphoryl)-5,5-difluoro-4-oxo-pentanoic acid benzyl ester

Guidance literature:

[(diethoxyphosphoryl)difluoromethyl]zinc bromide; With copper(I) bromide; In 1,2-dimethoxyethane; acetonitrile; at -5 ℃; for 1h;

N-(benzyloxycarbonyl)-L-aspartic acid-4-chloride-1-benzyl ester; With lithium bromide; In 1,2-dimethoxyethane; acetonitrile; at 20 ℃;

DOI:10.1055/s-2003-38743

upstream raw materials:

diethyl (bromodifluoromethyl)phosphonate

Downstream raw materials:

Diethyl difluoromethylphosphonate

diethyl (bromodifluoromethyl)phosphonate

diethyl 1,1-difluoro-1-chloromethylphosphonate

difluoro(diethoxyphosphoryl)acetyl chloride

Refernces

• 1、 Tsai, Hou-Jen. "Preparation and synthetic application of diethyl 2-oxo-1,1-difluorophosphonates". . p. 247 - 259. Retrieved 2007/10/03.