(CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER

Base Information

• Chemical Name: (CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER
• CAS No.: 97480-49-4
• Molecular Formula: C6H10 Cl F2 O4 P
• Molecular Weight: 250.567
• Hs Code.: 2931900090
• Mol file: 97480-49-4.mol

Synonyms:(CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER;Difluoro(diethoxyphosphinyl)acetylchloride;(Chlorocarbonyldifluoromethyl)phosphonic acid diethyl ester 97%;(Chlorocarbonyldifluoromethyl)phosphonicaciddiethylester97%;(Chlorocarbonyldifluoromethyl)phosphonic acid;DIFLUORO(DIETHOXYPHOSPINYL)ACETYL CHLORIDE

Chemical Property of (CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0835mmHg at 25°C
• Boiling Point: 226.1°C at 760 mmHg
• Flash Point: 90.5°C
• PSA: 62.41000
• Density: 1.362g/cm³
• LogP: 2.61070

Purity/Quality:

97% ^*data from raw suppliers

(CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER

There total 2 articles about (CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Diethyl phosphoryl-2,2-difluoroacetic acid (97480-37-0) → difluoro(diethoxyphosphoryl)acetyl chloride (97480-49-4)

Guidance literature:

With oxalyl dichloride; In benzene; for 20h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.05.001

Reference yield:

phosgene (75-44-5) + [(diethoxyphosphoryl)difluoromethyl]zinc bromide (82845-20-3) → Diethyl difluoromethylphosphonate (1478-53-1) + diethyl (bromodifluoromethyl)phosphonate (65094-22-6) + diethyl 1,1-difluoro-1-chloromethylphosphonate (113161-60-7) + difluoro(diethoxyphosphoryl)acetyl chloride (97480-49-4)

Guidance literature:

In 1,2-dimethoxyethane; toluene; for 17h; Ambient temperature;

DOI:10.1021/jo00242a034

Reference yield: 98.0%

2,4-difluorophenylamine (367-25-9,76563-56-9) + difluoro(diethoxyphosphoryl)acetyl chloride (97480-49-4) → diethyl 2-(2,4-difluorophenylamino)-1,1-difluoro-2-oxoethylphosphonate (1217898-93-5)

Guidance literature:

With pyridine; dmap; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.jfluchem.2009.05.001

upstream raw materials:

phosgene

[(diethoxyphosphoryl)difluoromethyl]zinc bromide

Diethyl phosphoryl-2,2-difluoroacetic acid

Downstream raw materials:

diethyl 2-(2,4-difluorophenylamino)-1,1-difluoro-2-oxoethylphosphonate

C₂₅H₃₂F₄N₂O₈P₂

diethyl 2-(benzylamino)-1,1-difluoro-2-oxoethylphosphonate