Oxazole, 2-(2-chlorophenyl)-4,5-dihydro-

Base Information

• Chemical Name: Oxazole, 2-(2-chlorophenyl)-4,5-dihydro-
• CAS No.: 82891-76-7
• Molecular Formula: C9H8ClNO
• Molecular Weight: 181.622
• Mol file: 82891-76-7.mol

Synonyms:

Chemical Property of Oxazole, 2-(2-chlorophenyl)-4,5-dihydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Oxazole, 2-(2-chlorophenyl)-4,5-dihydro-

There total 7 articles about Oxazole, 2-(2-chlorophenyl)-4,5-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-chloro-benzaldehyde (89-98-5) + ethanolamine (141-43-5) → 2-(2-chlorophenyl)-4,5-dihydrooxazole (82891-76-7)

Guidance literature:

With pyridinium hydrobromide perbromide; at 20 ℃; for 13h;

DOI:10.1055/s-2006-941597

Reference yield: 49.0%

o-chlorobenzoyl chloride (609-65-4) + ethanolamine (141-43-5) → 2-(2-chlorophenyl)-4,5-dihydrooxazole (82891-76-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b02689

Reference yield:

C9H10ClNOS → 2-(2-chlorophenyl)-4,5-dihydrooxazole (82891-76-7)

Guidance literature:

With potassium carbonate; In water; at 80 ℃;

DOI:10.1055/s-0032-1317341

upstream raw materials:

2-Chloro-N-(2-chloro-ethyl)-benzamide

2-chloro-benzaldehyde

ethanolamine

o-chlorobenzoyl chloride

Downstream raw materials:

2-(2-Propyl-phenyl)-4,5-dihydro-oxazole

2-(o-tolyl)-4,5-dihydrooxazole