Ethanolamine

Base Information

• Chemical Name: Ethanolamine
• CAS No.: 141-43-5
• Deprecated CAS: 9007-33-4,2122854-11-7,2169804-94-6
• Molecular Formula: C2H7NO
• Molecular Weight: 61.0837
• Hs Code.: 29221100
• European Community (EC) Number: 205-483-3,602-036-8,602-038-9,618-436-0,682-672-0,685-828-6,690-571-8
• ICSC Number: 0152
• UN Number: 2491
• UNII: 5KV86114PT
• DSSTox Substance ID: DTXSID6022000
• Nikkaji Number: J2.536D
• Wikipedia: Ethanolamine
• Wikidata: Q410387
• NCI Thesaurus Code: C61756
• RXCUI: 24457
• Metabolomics Workbench ID: 37102
• ChEMBL ID: CHEMBL104943
• Mol file: 141-43-5.mol

Synonyms:2 Aminoethanol;2-Aminoethanol;Colamine;Ethanolamine;Monoethanolamine

Chemical Property of Ethanolamine

Chemical Property:

• Appearance/Colour: clear liquid
• Vapor Pressure: 0.2 mm Hg ( 20 °C)
• Melting Point: 10-11 °C(lit.)
• Refractive Index: n20/D 1.454(lit.)
• Boiling Point: 170.9 °C at 760 mmHg
• PKA: 9.5(at 25℃)
• Flash Point: 93.3 °C
• PSA: 46.25000
• Density: 0.973 g/cm³
• LogP: -0.36230
• Storage Temp.: Store at RT.
• Sensitive.: Air Sensitive & Hygroscopic
• Solubility.: Soluble in benzene, ether, carbon tetrachloride.
• Water Solubility.: miscible
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 61.052763847
• Heavy Atom Count: 4
• Complexity: 10
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Ethanolamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,T
• Hazard Codes: T,C
• Statements: 20/21/22-34-39/23/24/25-23/24/25-10-52/53
• Safety Statements: 26-36/37/39-45-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Ethanolamines
• Canonical SMILES: C(CO)N
• Inhalation Risk: A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.
• Effects of Short Term Exposure: The substance is corrosive to the skin and eyes. Corrosive on ingestion. The vapour is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. This may result in lowering of consciousness.
• Description: Ethanolamine is a kind of viscous hygroscopic amino alcohol contains both amine and alcohol chemical groups. It is widely distributed inside the body and is a component of lecithin. It has many kinds of industrial applications. For example, it can be used in the production of agricultural chemicals including ammonia as well as the manufacturing of pharmaceuticals and detergents. It can also be used as a surfactant, fluorimetric reagent and removing agent of CO2 and H2S. In pharmaceutical field, ethanolamine is used as a Vascular Sclerosing agent. It also has antihistaminic property, which alleviates the negative symptoms caused by H1-receptor binding. Monoethanolamine is contained in many products, such as metalwork fluids. It is mainly an irritant. Traces may exist in other ethanolamine fluids.
• Physical properties: Monoethanolamine and triethanolamine are viscous, colorless, clear, hygroscopic liquids at room temperature; diethanolamine is a crystalline solid. All ethanolamines absorb water and carbon dioxide from the air and are infinitely miscible with water and alcohols. The freezing points of all ethanolamines can be lowered considerably by the addition of water. Ethanolamines are used widely as intermediates in the production of surfactants, which have become commercially important as detergents, textile and leather chemicals, and emulsifiers. Their uses range from drilling and cutting oils to medicinal soaps and highquality toiletries. Colorless, viscous, hygroscopic liquid with an unpleasant, mild, ammonia-like odor. Odor threshold concentration is 2.6 ppm (quoted, Amoore and Hautala, 1983). The lowest taste threshold concentration in potable water at 40 °C was 2.4 mg/L (Alexander et al., 1982).
• Uses: Ethanolamine is used as an absorption agent to remove carbon dioxide and hydrogen sulfide from natural gas and other gases, as a softening agent for hides, and as a dispersing agent for agricultural chemicals. Ethanolamine is also used in polishes, hair waving solutions, emulsifiers, and in the synthesis of surface-active agents (Beyer et al 1983; Mullins 1978; Windholz 1983). Ethanolamine is permitted in articles intended for use in the production, processing, or packaging of food (CFR 1981). Ethanolamine undergoes reactions characteristic of primary amines and of alcohols. Two industrially important reactions of ethanolamine involve reaction with carbon dioxide or hydrogen sulfide to yield water soluble salts, and reaction with long chain fatty acids to form neutral ethanolamine soaps (Mullins 1978). Substituted ethanolamine compounds, such as soaps, are used extensively as emulsifiers, thickeners, wetting agents, and detergents in cosmetic formulations (including skin cleaners, creams, and lotions) (Beyer et al 1983). Monoethanolamine is used as a dispersing agent for agricultural chemicals, in thesynthesis of surface-active agents, as a softening agent for hides, and in emulsifiers,polishes, and hair solutions. As a chemical intermediate; corrosion inhibitor; in the production of cosmetics, detergents, paints, and polishes Used as buffer; removal of carbon dioxide and hydrogen sulfide from gas mixtures.

Technology Process of Ethanolamine

There total 166 articles about Ethanolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-(3-nitrophenoxy)ethanamine (26646-35-5) → C8H9N2O3(1-) + meta-nitrophenol (554-84-7) + N-(2-hydroxyethyl)-3-nitroaniline (55131-09-4) + ethanolamine (141-43-5)

Guidance literature:

With deuteriated sodium hydroxide; In water-d2; at 20 ℃; for 0.833333h; UV-irradiation;

DOI:10.1021/ol051941p

Reference yield: 58.0%

sulfuric acid mono-(2-amino-ethyl ester) (926-39-6) + carbon dioxide (124-38-9,18923-20-1) → dimethylenecyclourethane (497-25-6) + Tau (107-35-7) + ethanolamine (141-43-5)

Guidance literature:

With sodium hydrogensulfite; sodium hydroxide; In water; at 150 ℃; for 1.5h; under 10343.2 Torr; Inert atmosphere;

Reference yield: 14.0%

2-(Ethylamino)ethanol (110-73-6) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylamine (75-04-7,85404-22-4) + ethanolamine (141-43-5) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With water; at 25 ℃; Further byproducts given; anodic oxidation, pH 10, carbonate buffer;

upstream raw materials:

oxirane

ethyleneimine

tetrachloromethane

triethanolamine

Downstream raw materials:

monoethyl ether of triethylene glycol

3,6,9,12-tetraoxatetradecan-1-ol

triethanolamine

2-(2-Aminoethylamino)ethanol

Refernces

• 1、 Mishra, Vedprakash S.,Joshi, Jyeshtharaj B.,Mahajani, Vijaykumar V.. "KINETICS OF WET AIR OXIDATION OF DIETHANOLAMINE AND MORPHOLINE". . p. 1601 - 1608. Retrieved 1994.
• 2、 Ohrui,Itoh,Nishida,Horie,Meguro. "Potential D,L-amino acid sequence analysis of peptides from the C-terminus". . p. 392 - 395. Retrieved 1997.
• 3、 Antelo, J.M.,Arce, F.,Casal, D.,Rodriguez, P.,Varela, A.. "INFLUENCE OF pH ON THE DECOMPOSITION OF N-CHLORODIETHANOLAMINE". . p. 3955 - 3966. Retrieved 1989.
• 4、 Munegumi, Toratane,Nishi, Nobuyuki,Harada, Kaoru. "Oxidation of Ethylamine to Glycine in Aqueous Solution Induced by KrF Excimer Laser Irradiation". . p. 1689 - 1690. Retrieved 1990.
• 5、 Porciúncula González, Cecilia,Castilla, Agustín,Garófalo, Lucía,Soule, Silvia,Irazoqui, Gabriela,Giacomini, Cecilia. "Enzymatic synthesis of 2-aminoethyl β-d-galactopyranoside catalyzed by Aspergillus oryzae β-galactosidase". . p. 104 - 110. Retrieved 2013.
• 6、 Jarmelo,Fausto. "Entropy effects in conformational distribution and conformationally dependent UV-induced photolysis of serine monomer isolated in solid argon". . p. 175 - 181. Retrieved 2006.
• 7、 Kroutil, Jiri,Trnka, Tomas,Cerny, Miloslav. "Improved Procedure for the Selective N-Debenzylation of Benzylamines by Diisopropyl Azodicarboxylate". . p. 446 - 450. Retrieved 2004.
• 8、 Matveev. "-". . . Retrieved 1969.
• 9、 Lai, Chuan,Xie, Bin,Guo, Xiaogang. "Research on hydroxyethyl ammonium O,O′-diphenyl dithiophosphate: Synthesis, characterization, surface activity and corrosion inhibition performance". . p. 107 - 114. Retrieved 2020.
• 10、 -. "Cyclic process for producing taurine from monoethanolamine". Page/Page column 14-15. . Retrieved 2022/03/22.