(2R,5S)-5-hydroxypiperidine-2-carboxylic acid

Base Information

• Chemical Name: (2R,5S)-5-hydroxypiperidine-2-carboxylic acid
• CAS No.: 17027-46-2
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.158
• Mol file: 17027-46-2.mol

Synonyms:2-Piperidinecarboxylicacid, 5-hydroxy-, trans-; Pipecolic acid, 5-hydroxy-,trans- (8CI); trans-5-Hydroxypipecolic acid

Chemical Property of (2R,5S)-5-hydroxypiperidine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.87E-06mmHg at 25°C
• Boiling Point: 354.8°C at 760 mmHg
• Flash Point: 168.4°C
• Density: 1.299g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,5S)-5-hydroxypiperidine-2-carboxylic acid

There total 5 articles about (2R,5S)-5-hydroxypiperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxypicolinic acid (15069-92-8) → rac-(2R*,5S*)-5-hydroxypiperidine-2-carboxylic acid (13096-31-6,17027-45-1,17027-46-2,50439-45-7,63088-78-8,138662-60-9,448964-01-0,478409-64-2) + (cis)-5-hydroxypiperidine-2-carboxylic acid (13096-31-6,17027-45-1,17027-46-2,50439-45-7,63088-78-8,138662-60-9,448964-01-0,478409-64-2)

Guidance literature:

With platinum(IV) oxide; ammonium hydroxide; hydrogen; In water; at 50 ℃; for 96h; under 7600.51 Torr; Overall yield = 99 percent; Overall yield = 1.30 kg; Autoclave;

DOI:10.1021/acs.oprd.1c00098

Reference yield:

5-hydroxypicolinic acid (15069-92-8) → rac-(2R*,5S*)-5-hydroxypiperidine-2-carboxylic acid (13096-31-6,17027-45-1,17027-46-2,50439-45-7,63088-78-8,138662-60-9,448964-01-0,478409-64-2) + (cis)-5-hydroxypiperidine-2-carboxylic acid (13096-31-6,17027-45-1,17027-46-2,50439-45-7,63088-78-8,138662-60-9,448964-01-0,478409-64-2)

Guidance literature:

With platinum(IV) oxide; ammonium hydroxide; hydrogen; In water; at 50 ℃; for 96h; under 7600.51 Torr; Overall yield = 99 percent; Overall yield = 1.30 kg; Autoclave;

DOI:10.1021/acs.oprd.1c00098

Reference yield:

→ rac-(2R*,5S*)-5-hydroxypiperidine-2-carboxylic acid (13096-31-6,17027-45-1,17027-46-2,50439-45-7,63088-78-8,138662-60-9,448964-01-0,478409-64-2)

Guidance literature:

With methanol; sodium tetrahydroborate;

upstream raw materials:

5-hydroxypicolinic acid

Downstream raw materials:

2R,5S-5-hydroxy-piperidine-2-carboxylic acid

(2S,5R)-5-hydroxy-2-piperidinecarboxylic acid

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