N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea

Base Information

Chemical Name:N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea
CAS No.:83019-67-4
Molecular Formula:C18H23N3O3
Molecular Weight:329.399
Hs Code.:
ChEMBL ID:CHEMBL279883
DSSTox Substance ID:DTXSID80515723

Synonyms:83019-67-4;CHEMBL279883;SCHEMBL11649378;DTXSID80515723;N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea

Suppliers and Price of N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea

Chemical Property:

XLogP3:1.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:329.17394160
Heavy Atom Count:24
Complexity:342

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)NC(=O)NCCNCC(COC2=CC=CC=C2)O

Technology Process of N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea

There total 4 articles about N-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 122-60-1,71031-02-2
Phenyl glycidyl ether

: 85850-48-2
2-<<(phenylamino)carbonyl>amino>ethylamine hydrochloride

: 83019-67-4
1-[2-(2-Hydroxy-3-phenoxy-propylamino)-ethyl]-3-phenyl-urea

Guidance literature:: With sodium hydroxide; In propan-1-ol; water; at 90 ℃; for 0.5h;
DOI:10.1016/S0968-0896(03)00297-9

Reference yield: 18.0%

: 122-60-1,71031-02-2
Phenyl glycidyl ether

: 53673-01-1
1-(2-aminoethyl)-3-phenylurea

: 83019-67-4
1-[2-(2-Hydroxy-3-phenoxy-propylamino)-ethyl]-3-phenyl-urea

Guidance literature:: With sodium hydroxide; In propan-1-ol; for 18h; Heating;
DOI:10.1021/jm00353a004

Reference yield:

: 215654-49-2
tert-butyl (2-(3-phenylureido)ethyl)carbamate

: 83019-67-4
1-[2-(2-Hydroxy-3-phenoxy-propylamino)-ethyl]-3-phenyl-urea

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / methanol; H₂O / 2.5 h / 45 - 50 °C / 39.75 - 74.26 Torr

2: 30 percent / NaOH / propan-1-ol; H₂O / 0.5 h / 90 °C

With hydrogenchloride; sodium hydroxide; In methanol; propan-1-ol; water;
DOI:10.1016/S0968-0896(03)00297-9