4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-

Base Information

Chemical Name:4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-
CAS No.:70330-52-8
Molecular Formula:C₁₉H₂₃N₅O₂S
Molecular Weight:385.49
Hs Code.:
DSSTox Substance ID:DTXSID30220613
Wikidata:Q83097928

Synonyms:BRN 6008329;4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-;70330-52-8;SCHEMBL11456852;C19H23N5O2S;DTXSID30220613;ZHLZQKOEXGHQDY-UHFFFAOYSA-N;LS-135963;2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-methoxybenzyl)-4-pyrimidone

Suppliers and Price of 4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-

Chemical Property:

Density:1.31g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:385.15724617
Heavy Atom Count:27
Complexity:568

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N=CN1)CSCCNC2=NC=C(C(=O)N2)CC3=CC=CC=C3OC

Technology Process of 4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)-

There total 6 articles about 4(1H)-Pyrimidinone, 5-((2-methoxyphenyl)methyl)-2-((2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)amino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 70311-29-4
5-(2-methoxybenzyl)-2-methylthio-4-pyrimidone

: 38585-67-0
4-{[(2-aminoethyl)thio]methyl}-5-methylimidazole

: 70330-52-8
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-methoxybenzyl)-4-pyrimidone

Guidance literature:: at 140 - 150 ℃; for 5h;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 24393-54-2
ethyl 3-(2-methoxyphenyl)prop-2-enoate

: 70330-52-8
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-methoxybenzyl)-4-pyrimidone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / 5percent Pd/C / ethanol

2: sodium wire / diethyl ether / 18 h / Ambient temperature

3: ethanol / 7 h / Heating

4: 74 percent / aq. NaOH / ethanol / 60 °C

5: 21 percent / 5 h / 140 - 150 °C

With sodium hydroxide; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 135-02-4
ortho-anisaldehyde

: 70330-52-8
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(2-methoxybenzyl)-4-pyrimidone

Guidance literature:: Multi-step reaction with 6 steps

1: 1) piperidine, 2) conc. H₂SO₄ / 1) pyridine

2: hydrogen / 5percent Pd/C / ethanol

3: sodium wire / diethyl ether / 18 h / Ambient temperature

4: ethanol / 7 h / Heating

5: 74 percent / aq. NaOH / ethanol / 60 °C

6: 21 percent / 5 h / 140 - 150 °C

With piperidine; sodium hydroxide; sulfuric acid; hydrogen; sodium; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5