Butanoic acid, 4,4'-[[5-[(1E)-2-carboxyethenyl]-1,3-phenylene]diimino]bis[4-oxo-, 1,1'-bis[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester

Base Information

• Chemical Name: Butanoic acid, 4,4'-[[5-[(1E)-2-carboxyethenyl]-1,3-phenylene]diimino]bis[4-oxo-, 1,1'-bis[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester
• CAS No.: 831179-87-4
• Molecular Formula: C37H54N2O8
• Molecular Weight: 654.844
• Mol file: 831179-87-4.mol

Synonyms:

Chemical Property of Butanoic acid, 4,4'-[[5-[(1E)-2-carboxyethenyl]-1,3-phenylene]diimino]bis[4-oxo-, 1,1'-bis[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 4,4'-[[5-[(1E)-2-carboxyethenyl]-1,3-phenylene]diimino]bis[4-oxo-, 1,1'-bis[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester

There total 8 articles about Butanoic acid, 4,4'-[[5-[(1E)-2-carboxyethenyl]-1,3-phenylene]diimino]bis[4-oxo-, 1,1'-bis[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N-{3-((E)-2-Allyloxycarbonyl-vinyl)-5-[3-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-propionylamino]-phenyl}-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (831179-82-9) → N-{3-((E)-2-Carboxy-vinyl)-5-[3-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-propionylamino]-phenyl}-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (831179-87-4)

Guidance literature:

With ammonium formate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; for 8h; Heating;

DOI:10.1021/jo048799a

Reference yield:

L-menthylsuccinic acid (77341-67-4) → N-{3-((E)-2-Carboxy-vinyl)-5-[3-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-propionylamino]-phenyl}-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (831179-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazole-1-yl-oxy-tris-(dimethylamino) PF₆; DiPEA / acetonitrile

2: ammonium formate; PPh₃ / tetrahydrofuran

With benzotriazole-1-yl-oxy-tris-(dimethylamino) PF₆; ammonium formate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.3390/10010081

Reference yield:

3,5-dinitrobenzaldehyde (14193-18-1) → N-{3-((E)-2-Carboxy-vinyl)-5-[3-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-propionylamino]-phenyl}-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (831179-87-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / Heating

2: SnCl₂ / tetrahydrofuran; H₂O / Heating

3: benzotriazole-1-yl-oxy-tris-(dimethylamino) PF₆; DiPEA / acetonitrile

4: ammonium formate; PPh₃ / tetrahydrofuran

With benzotriazole-1-yl-oxy-tris-(dimethylamino) PF₆; ammonium formate; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tin(ll) chloride; In tetrahydrofuran; water; acetonitrile;

DOI:10.3390/10010081

upstream raw materials:

N-{3-((E)-2-Allyloxycarbonyl-vinyl)-5-[3-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxycarbonyl)-propionylamino]-phenyl}-succinamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

(-)-menthol

3,5-dinitrobenzoic acid

3,5-dinitrobenzaldehyde