2-Propanone, 1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy ]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]-, (1R)-

Base Information

Chemical Name:2-Propanone, 1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy ]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]-, (1R)-
CAS No.:832078-93-0
Molecular Formula:C27H46O8Si
Molecular Weight:526.743
Hs Code.:

Synonyms:(R)-1-((1R,2R,3R,5R)-2,3-Bis-methoxymethoxy-3-methyl-5-triethylsilanyloxy-cyclopentyl)-1-(4-methoxy-benzyloxy)-propan-2-one;(R)-1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-(triethylsilyloxy)cyclopentyl]-1-(4-methoxybenzyloxy)propan-2-one;

Suppliers and Price of 2-Propanone, 1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy ]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]-, (1R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Propanone, 1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy ]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]-, (1R)-

Chemical Property:

PSA：81.68000
LogP:4.94800

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Propanone, 1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy ]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]-, (1R)-

There total 22 articles about 2-Propanone, 1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy ]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]-, (1R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 917-54-4
methyllithium

: 832078-92-9
(R)-2-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-(triethylsilyloxy)cyclopentyl]-2-(4-methoxybenzyloxy)-1-(pyrrolidin-1-yl)ethanone

: 832078-93-0
(1R)-1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]propan-2-one

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.25h;
DOI:10.1055/s-2004-834822 DOI:10.1002/hlca.200590124

Reference yield:

: 59995-48-1
(R)-4-acetoxycyclopent-2-en-1-one

: 832078-93-0
(1R)-1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]propan-2-one

Guidance literature:: Multi-step reaction with 17 steps

1.1: 99 percent / K₂CO₃ / methanol

2.1: 86 percent / Et₃N; DMAP

3.1: 85 percent / toluene / 48 h / Heating

4.1: 80 percent / 18-crown-6; oxone; aq. NaHCO₃ / acetone; CH₂Cl₂ / 2 h / 0 °C

5.1: 81 percent / i-Pr₂NEt / CH₂Cl₂ / 48 h / 20 °C

6.1: 92 percent / pyridine

7.1: 73 percent / TBAF

8.1: 79 percent / CSA

9.1: 89 percent / K₂CO₃ / methanol

10.1: 86 percent / i-Pr₂NEt; NaI / CH₂Cl₂ / 18 h / Heating

11.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C

11.2: 2-benzenesulfonyl-3-(3-nitrophenyl)oxaziridine / tetrahydrofuran; toluene / 0.5 h / -78 °C

11.3: 74 percent / CSA / tetrahydrofuran; toluene / 1 h / -78 - 20 °C

12.1: 87 percent / CSA / CH₂Cl₂ / 18 h / 20 °C

13.1: 91 percent / toluene / 18 h / Heating

14.1: 88 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

15.1: 81 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With pyridine; dmap; Oxone; 18-crown-6 ether; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone; toluene; 4.1: Claisen-Eschenmoser rearrangement;
DOI:10.1055/s-2004-834822

Reference yield:

: 832078-84-9
2-[(1S,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}3-mehylcyclopent-2-en-1-yl]-N,N-dimethylacetamide

: 832078-93-0
(1R)-1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]propan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 80 percent / 18-crown-6; NaHCO₃; potassium peroxymonosulfate / CH₂Cl₂; acetone; H₂O / 2 h / 0 °C

2.1: 81 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

3.1: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / 20 °C

4.1: 86 percent / diisopropylethylamine; NaI / CH₂Cl₂ / 18 h / Heating

5.1: potassium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

5.2: 3-(3-nitrophenyl)-2-(phenylsulfonyl)-1,2-oxaziridine / tetrahydrofuran / 0.5 h / -78 °C

5.3: 74 percent / chlorosulfonic acid / tetrahydrofuran / 1 h / -78 - 20 °C

6.1: 87 percent / chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

7.1: 91 percent / toluene / 18 h / Heating

8.1: 88 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

9.1: 81 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With pyridine; chlorosulfonic acid; Oxone; potassium hexamethyldisilazane; 18-crown-6 ether; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene;
DOI:10.1002/hlca.200590124