832078-92-9

Upstream product

• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 120520-91-4 (1R,4S)-4-(tert-butyldimethylsilyloxy)cyclopent-2-enol 
• 104069-09-2 (1S,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enol 
• 103729-50-6 (1R,3S)-(-)-1-acetoxycyclopentan-3-ol 
• 832078-94-1 2-[(1S,2R,3R,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-3-methoxymethoxy-3-methyl-cyclopentyl]-1-pyrrolidin-1-yl-ethanone 
• 832078-95-2 Acetic acid (1R,2R,4R,5R)-4-hydroxy-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester 
• 832078-96-3 Acetic acid (3aR,4R,5R,6aR)-5-methoxymethoxy-5-methyl-2-oxo-hexahydro-cyclopenta[b]furan-4-yl ester 
• 115074-49-2 (1R,4S)-4-[(tert-butyldimethylsilyl)oxy]-2-cyclopentene-1-yl acetate 
• 61305-35-9 (R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone 
• 59995-48-1 (R)-4-acetoxycyclopent-2-en-1-one 
• 59995-47-0 (R)-(+)-4-hydroxy-2-cyclopentenone 
• 832078-87-2 Acetic acid (1R,2R,4R,5S)-4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-2-methyl-5-(2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester 
• 832078-90-7 (3R,3aR,4R,5R,6aR)-3,3a,4,5,6,6a-hexahydro-3-[(4-methoxybenzyl)oxy]-4,5-bis(methoxymethoxy)-5-methyl-2H-cyclopenta[b]furan-2-one 
• 832078-86-1 (3aS,4R,6R,6aR)-4-{[tert-butyl(dimethyl)silyl]oxy}-3,3a,4,5,6,6a-hexahydro-6-(methoxymethoxy)-6-methyl-2H-cyclopenta[b]furan-2-one 

Downstream Products

• 832078-93-0 (1R)-1-[(1R,2R,3R,5R)-2,3-bis(methoxymethoxy)-3-methyl-5-[(triethylsilyl)oxy]cyclopentyl]-1-[(4-methoxyphenyl)methoxy]propan-2-one 

Relevant academic research and scientific papers

Toward a total synthesis of macrocyclic jatrophane diterpenes - Concise route to a highly functionalized cyclopentane key intermediate

A total synthesis of the biologically potent jatrophane diterpenes pepluanin A (1) and euphosalicin A (2) is being aimed at. En route to these targets, a concise synthesis of the nonracemic cyclopentane building block 74 was developed. Key steps were a Cl

Toward the total syntheses of pepluanin A and euphosalicin: Concise route to a highly oxygenated cyclopentane as a common intermediate

A substrate controlled asymmetric synthesis is described of a highly functionalized cyclopentanyl vinyl triflate which serves as an advanced intermediate in the total synthesis of the novel multidrug resistance reversing jatrophanes pepluanin A and euphosalicin. Key steps are a Claisen-Eschenmoser rearrangement followed by hydroxy-lactonization, intramolecular trans-lactonization, Davis hydroxylation and regioselective enoltriflate formation.