Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Base Information

Chemical Name:Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-
CAS No.:832102-97-3
Molecular Formula:C20H20N2OS
Molecular Weight:336.458
Hs Code.:
DSSTox Substance ID:DTXSID00475491
Wikidata:Q82306060

Synonyms:832102-97-3;Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-;SCHEMBL6231990;DTXSID00475491;FT-0731341

Suppliers and Price of Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:336.12963444
Heavy Atom Count:24
Complexity:443

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C2=CC=CC=C2)C(=O)C3=CC4=C(S3)C=CC(=C4)N

Technology Process of Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

There total 5 articles about Piperidine, 1-[(5-aminobenzo[b]thien-2-yl)carbonyl]-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 832102-96-2
1-[(5-nitro-1-benzothien-2-yl)carbonyl]-4-phenylpiperidine

: 832102-97-3
{2-[(4-phenyl-1-piperidinyl)carbonyl]-1-benzothien-5-yl}amine

Guidance literature:: With hydrogen; Pd/C; In methanol; at 20 ℃; for 4h; under 2068.59 Torr;
DOI:10.1021/jm060814b

Reference yield:

: 20699-86-9
methyl 5-nitrobenzo[b]thiophene-2-carboxylate

: 832102-97-3
{2-[(4-phenyl-1-piperidinyl)carbonyl]-1-benzothien-5-yl}amine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

3: hydrogen / Pd/C / methanol / 4 h / 20 °C / 2068.59 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; Pd/C; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm060814b

Reference yield:

: 6345-55-7
5-nitrobenzo[b]thiophene-2-carboxylic acid

: 832102-97-3
{2-[(4-phenyl-1-piperidinyl)carbonyl]-1-benzothien-5-yl}amine

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

2: hydrogen / Pd/C / methanol / 4 h / 20 °C / 2068.59 Torr

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; Pd/C; In methanol; dichloromethane;
DOI:10.1021/jm060814b