Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Base Information

Chemical Name:Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl-
CAS No.:832102-96-2
Molecular Formula:C20H18N2O3S
Molecular Weight:366.441
Hs Code.:
DSSTox Substance ID:DTXSID80475454
Wikidata:Q82305995

Synonyms:832102-96-2;Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl-;SCHEMBL6252866;DTXSID80475454;FT-0728122

Suppliers and Price of Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:366.10381361
Heavy Atom Count:26
Complexity:524

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C2=CC=CC=C2)C(=O)C3=CC4=C(S3)C=CC(=C4)[N+](=O)[O-]

Technology Process of Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl-

There total 3 articles about Piperidine, 1-[(5-nitrobenzo[b]thien-2-yl)carbonyl]-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771-99-3
4-phenylpiperidine

: 6345-55-7
5-nitrobenzo[b]thiophene-2-carboxylic acid

: 832102-96-2
1-[(5-nitro-1-benzothien-2-yl)carbonyl]-4-phenylpiperidine

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm060814b

Reference yield:

: 20699-86-9
methyl 5-nitrobenzo[b]thiophene-2-carboxylate

: 832102-96-2
1-[(5-nitro-1-benzothien-2-yl)carbonyl]-4-phenylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060814b

Reference yield:

: 6361-21-3
2-chloro-5-nitrobenzaldehyde

: 832102-96-2
1-[(5-nitro-1-benzothien-2-yl)carbonyl]-4-phenylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C

2: lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With potassium hydroxide; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm060814b