Technology Process of Pyridine,
2-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]-, 1-oxide
There total 7 articles about Pyridine,
2-[3-[(1R)-1-methoxy-1-phenylethyl]-5-methyl-1H-pyrazol-1-yl]-, 1-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-3(5)-(1-methoxy-1-phenyl-ethyl)-5(3)-methyl-1H-pyrazole;
With
potassium;
In
toluene;
at 80 ℃;
2-chloropyridine-N-oxide;
In
N,N-dimethyl-formamide; toluene;
at 60 ℃;
for 22h;
DOI:10.1016/j.tet.2004.10.092
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: K2CO3; Adogen / toluene / 20 - 90 °C
2.1: LDA / tetrahydrofuran / -60 - 0 °C
2.2: tetrahydrofuran / 18 h / -60 - 20 °C
3.1: aq. NaOH / ethanol
3.2: 28.7 g / aq. HCl
4.1: Brucine / acetone
4.2: aq. HCl
5.1: 84 percent / DOWEX X50-H(+) / methanol / 10 h / Heating
6.1: sodium hydride / diethyl ether / 1.5 h / 25 °C
6.2: 78 percent Chromat. / diethyl ether / 1.58 h
7.1: 60 percent / hydrazine monohydrate / ethanol / 0.5 h / Heating
8.1: potassium / toluene / 80 °C
8.2: 47 percent / dimethylformamide; toluene / 22 h / 60 °C
With
sodium hydroxide; DOWEX X50-H(+); triisooctyl amine; potassium; sodium hydride; potassium carbonate; hydrazine hydrate; brucine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; acetone; toluene;
DOI:10.1016/j.tet.2004.10.092
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aq. NaOH / ethanol
1.2: 28.7 g / aq. HCl
2.1: Brucine / acetone
2.2: aq. HCl
3.1: 84 percent / DOWEX X50-H(+) / methanol / 10 h / Heating
4.1: sodium hydride / diethyl ether / 1.5 h / 25 °C
4.2: 78 percent Chromat. / diethyl ether / 1.58 h
5.1: 60 percent / hydrazine monohydrate / ethanol / 0.5 h / Heating
6.1: potassium / toluene / 80 °C
6.2: 47 percent / dimethylformamide; toluene / 22 h / 60 °C
With
sodium hydroxide; DOWEX X50-H(+); potassium; sodium hydride; hydrazine hydrate; brucine;
In
methanol; diethyl ether; ethanol; acetone; toluene;
DOI:10.1016/j.tet.2004.10.092
