2402-95-1Relevant articles and documents
Au(I)-Catalyzed Oxidative Functionalization of Yndiamides
Tong, Zixuan,Garry, Olivia L.,Smith, Philip J.,Jiang, Yubo,Mansfield, Steven J.,Anderson, Edward A.
supporting information, p. 4888 - 4892 (2021/06/28)
Yndiamides, underexplored cousins of ynamides, offer rich synthetic potential as doubly nitrogenated two carbon building blocks. Here we report a gold-catalyzed oxidative functionalization of yndiamides to access unnatural amino acid derivatives, using a wide range of nucleophiles as a source of the amino acid side chain. The transformation proceeds under mild conditions, is highly functional group tolerant, and displays excellent regioselectivity through subtle steric differentiation of the yndiamide nitrogen atom substituents.
Recyclable anhydride catalyst for H2O2 oxidation:: N -oxidation of pyridine derivatives
Gajeles, Ghellyn,Kim, Se Mi,Lee, Kyung-Koo,Lee, Sang Hee,Yoo, Jong-Cheol
, p. 9165 - 9171 (2020/03/13)
The catalytic efficiency and recyclability of poly(maleic anhydride-alt-1-octadecene) (Od-MA) and poly(maleic anhydride-alt-1-isobutylene) (Bu-MA) were evaluated for use in the development of a metal-free, reusable catalyst for the oxidation of pyridines to pyridine N-oxides in the presence of H2O2. The Od-MA catalyst was easily recovered via filtration with recovery yields exceeding 99.8%. The catalyst retained its activity after multiple uses and did not require any treatment for reuse. The Od-MA and H2O2 catalytic system described herein is eco-friendly, operationally simple, and cost-effective; thus, it is industrially applicable. Od-MA and H2O2 could potentially be used in place of percarboxylic acid as an oxidant in a wide range of oxidation reactions.
Preparation method of 2-chloro-4-aminopyridine
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Paragraph 0016; 0019; 0020; 0023; 0024; 0028; 0029, (2020/05/05)
The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 2-chloro-4-aminopyridine. The preparation method comprises the following steps: (1) using 2-chloropyridine as a raw material and chloroform as a solvent, and generating 2-chloropyridine oxide under the action of m-chloroperoxybenzoic acid; (2) reacting 2-chloropyridine oxide with a mixed acid composed of concentrated nitric acid and concentrated sulfuric acid to generate 2-chloro-4-nitropyridine oxynitride; and (3) reducing 2-chloro-4-nitropyridine oxynitride into 2-chloro-4-aminopyridine. The method has the beneficial effects that the reaction conditions are mild, the operation is easy, the post-treatment is simple, the scale-up production is easy, the method is very suitable for industrial production; the catalytic effect is good, the yield is high; the raw materials are cheap, and the production cost is low.
