(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate

Base Information Edit

Chemical Name:(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate
CAS No.:23735-43-5
Molecular Formula:C13H18O5S
Molecular Weight:286.349
Hs Code.:29329990
European Community (EC) Number:624-409-4
DSSTox Substance ID:DTXSID90369097
Nikkaji Number:J1.490.364J
Wikidata:Q72469861
Mol file:23735-43-5.mol

Synonyms:23735-43-5;(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate;(S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate;(S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate;[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 4-methylbenzenesulfonate;(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-ylmethyl- p-toluenesulfonate;MFCD00063234;(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-ylmethyl p-Toluenesulfonate;(S)-(2,2-dimethyl-1,3-dioxalan-4-yl)methyl-4-methylbenzenesulfonate;[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 4-methylbenzene-1-sulfonate;((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate;SCHEMBL898388;(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate #;(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate;DTXSID90369097;(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate;BBL101173;GEO-01178;STL554969;AKOS005257643;AKOS015890122;CS-W012219;MS-20174;D2550;C74224;EN300-7403268;(2S)-1-O-Tosyl-2-O,3-O-isopropylideneglycerol;L-alpha,beta-Isopropylideneglycerol-gamma-tosylate;W-200245;L-(+)-1,2-Isopropylideneglycerol 3-(p-Toluenesulfonate);(S)-2,2-Dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate;(4s)-2,2-dimethyl-4-toluene-4-sulfonyloxymethyl 1,3-dioxolane;(S)-(+)-2,2-dimethyl-1,3-dioxolan-4-ylmethyl p-toluene sulfonate;(S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl4-methylbenzenesulfonate;(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate, 97%;(S)-toluene-4-sulfonic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester;[(4s)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 4-methyl-benzenesulfonate;[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 4-methylbenzene-sulfonate;para-toluenesulfonic acid (S)-2,2-dimethyl-[1,3]dioxolan-4-yl-methyl ester;para-toluenesulfonic acid (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester;toluene-4-sulfonic acid (S)-2,2-dimethyl-[1,3]dioxolan-4-yl-methyl ester;toluene-4-sulfonic acid (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester;(S)-2,2-Dimethyl-1,3-dioxolane-4-methanol p-toluenesulfonate, purum, >=99.0% (sum of enantiomers, GC)

Suppliers and Price of (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate
1g
$ 115.00

TCI Chemical
(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate >98.0%(GC)
5g
$ 389.00

TCI Chemical
(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate >98.0%(GC)
1g
$ 119.00

SynQuest Laboratories
(S)-2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxolane-p-toluenesulfonate
1 g
$ 109.00

Sigma-Aldrich
(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate 97%
5g
$ 338.00

Sigma-Aldrich
(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate 97%
1g
$ 110.00

Crysdot
(S)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl4-methylbenzenesulfonate 95+%
25g
$ 525.00

Chem-Impex
(S)-2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxolane-p-toluenesulfonate
1G
$ 124.63

Chemenu
(S)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl4-methylbenzenesulfonate 95%
25g
$ 496.00

Chemenu
(S)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl4-methylbenzenesulfonate 95%
10g
$ 248.00

Total 38 raw suppliers

Chemical Property of (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate Edit

Chemical Property:

Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:3.01E-06mmHg at 25°C
Melting Point:29-31 °C
Refractive Index:n20/D 1.506(lit.)
Boiling Point:400.1 °C at 760 mmHg
Flash Point:195.8 °C
PSA：70.21000
Density:1.198 g/cm³
LogP:2.93260
Storage Temp.:2-8°C
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:286.08749484
Heavy Atom Count:19
Complexity:390

Purity/Quality:

98%, ^*data from raw suppliers

(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCC2COC(O2)(C)C
Isomeric SMILES:CC1=CC=C(C=C1)S(=O)(=O)OC[C@@H]2COC(O2)(C)C
Uses (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate has been used as a reactant for the synthesis of 16-(3-trifluoromethyl)phenoxy PGF2α analog travoprost (T715600) which has potent topical ocular activity. (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate has also been used for the preparation of p38 mitogen activated protein (MAP) kinase inhibitors.

Technology Process of (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate

There total 17 articles about (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 98-59-9
p-toluenesulfonyl chloride

: 14347-78-5,36543-79-0
1,2-O-isopropylidene-D-glycerol

: 23735-43-5,7305-59-1
(S)-1-O-tosyl-2,3-O-isopropylideneglycerol

Guidance literature:: 1,2-O-isopropylidene-D-glycerol; With dmap; triethylamine; In dichloromethane; at 0 ℃;

p-toluenesulfonyl chloride; at 0 - 20 ℃;
DOI:10.1021/acsmedchemlett.9b00438