Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-hydroxyphenyl)-3,6- dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-hydroxyphenyl)-3,6- dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester
CAS No.:832711-52-1
Molecular Formula:C31H30F3N3O5
Molecular Weight:581.592
Hs Code.:

Carbamic acid,
[(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-hydroxyphenyl)-3,6-
dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-,
1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-hydroxyphenyl)-3,6- dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-hydroxyphenyl)-3,6- dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, [(1R)-2-[3-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-hydroxyphenyl)-3,6- dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₂F₃N₃O₃

: 24424-99-5
di-tert-butyl dicarbonate

: 832711-52-1
3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(2-fluoro-3-hydroxyphenyl)-1-[2,6-difluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With triethylamine; In dichloromethane; pH=> 8;

Reference yield:

: 832711-52-1
3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(2-fluoro-3-hydroxyphenyl)-1-[2,6-difluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

: 2067-33-6
5-bromopentanoic acid

: 832711-53-2
3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(2-fluoro-3-([4-hydroxycarbonyl]-1-butoxy)phenyl)-1-[2,6-difluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(2-fluoro-3-hydroxyphenyl)-1-[2,6-difluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione; 5-bromopentanoic acid; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 5h;

With lithium hydroxide; water; In methanol; DMF (N,N-dimethyl-formamide); at 80 ℃; for 1h;