2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate

Base Information

Chemical Name:2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate
CAS No.:83304-65-8
Molecular Formula:C18H23NO6
Molecular Weight:349.384
Hs Code.:
DSSTox Substance ID:DTXSID201131953

Synonyms:SCHEMBL11076847;DTXSID201131953;2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate;83304-65-8

Suppliers and Price of 2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:349.15253745
Heavy Atom Count:25
Complexity:510

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1(C(CC(=O)N1CC2=CC=CC=C2)(C)O)C(=O)OCC

Technology Process of 2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate

There total 4 articles about 2,2-Diethyl 3-hydroxy-3-methyl-5-oxo-1-(phenylmethyl)-2,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 5394-63-8
2,2,6-trimethyl-4H-1,3-dioxin-4-one

: 56599-00-9
diethyl N-benzyl-2-aminomalonate

: 83304-65-8
diethyl 1-benzyl-3-hydroxy-3-methyl-5-oxo-pyrrolidine-2,2-dicarboxylate

Guidance literature:: With acetic acid; In toluene; at 120 ℃; for 1h; Inert atmosphere;
DOI:10.1039/b803818j

Reference yield: 63.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 56599-00-9
diethyl N-benzyl-2-aminomalonate

: 83304-65-8
diethyl 1-benzyl-3-hydroxy-3-methyl-5-oxo-pyrrolidine-2,2-dicarboxylate

Guidance literature:: In acetic acid; Heating;
DOI:10.1016/S0040-4020(01)96442-7

Reference yield:

: 685-87-0
Diethyl 2-bromomalonate

: 83304-65-8
diethyl 1-benzyl-3-hydroxy-3-methyl-5-oxo-pyrrolidine-2,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / 1.5 h

2: 63 percent / acetic acid / Heating

With triethylamine; In acetic acid;
DOI:10.1016/S0040-4020(01)96442-7