10.1248/cpb.51.1025
The study focuses on the design and synthesis of uracil-based heterocyclic compounds, which are significant in organic and medicinal chemistry due to their therapeutic potential and presence in natural products with strategic biological functions. The researchers synthesized various 6-methyluracil derivatives with different substituents at the 1-position, aiming to create new biologically active compounds. Key chemicals used include substituted ureas, diketene, and piperazine derivatives, which serve as starting materials and building blocks for the synthesis of the target uracil derivatives. The purpose of these chemicals is to create a range of compounds with potential pharmacological actions, such as antineoplastic, antihypertensive, anti-inflammatory, antiviral, and reverse transcriptase inhibitory effects. The study also details the synthetic strategies and confirms the structures of the synthesized compounds through analytical and spectroscopic data.
10.1016/S0040-4039(02)00632-9
The research investigates the stereoretentive C-C bond formations in aldol cyclisations of 1-(3-oxobutyryl) derivatives of L-4-oxaproline and L-proline isopropyl esters. The purpose of the study was to explore the possibility of simplifying the self-generation of stereocenters in the synthesis of β-C-substituted β-amino acids, a class of compounds with wide-ranging biological properties, by leveraging the chirality memory effects observed in enolate intermediates. The researchers concluded that the aldol cyclisations conducted on oxaproline and proline scaffolds demonstrated significant retention of configuration, extending the scope of stereoinductions attributable to axially chiral enolate intermediates. Key chemicals used in the process included L-serine, isopropyl esters, L-oxaproline, L-proline, diketene, triethylamine, and potassium cyanide, among others. The study's findings are significant as they provide insights into the role of axially chiral enolate intermediates in stereoselective synthesis and contribute to the development of more efficient methods for producing enantioenriched β-C-substituted β-amino acids embedded in heterocyclic frameworks.