Adenosine, 3'-[[(2S)-2-(acetyloxy)-1-oxo-3-phenylpropyl]amino]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-3'-deoxy-N,N-dimethyl-, 2'-(hydrogen butanedioate)

Base Information

Chemical Name:Adenosine, 3'-[[(2S)-2-(acetyloxy)-1-oxo-3-phenylpropyl]amino]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-3'-deoxy-N,N-dimethyl-, 2'-(hydrogen butanedioate)
CAS No.:833447-74-8
Molecular Formula:C₄₈H₅₀N₆O₁₁
Molecular Weight:886.959
Hs Code.:

Adenosine,
3'-[[(2S)-2-(acetyloxy)-1-oxo-3-phenylpropyl]amino]-5'-O-[bis(4-methoxy
phenyl)phenylmethyl]-3'-deoxy-N,N-dimethyl-, 2'-(hydrogen
butanedioate)

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Adenosine, 3'-[[(2S)-2-(acetyloxy)-1-oxo-3-phenylpropyl]amino]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-3'-deoxy-N,N-dimethyl-, 2'-(hydrogen butanedioate)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Adenosine, 3'-[[(2S)-2-(acetyloxy)-1-oxo-3-phenylpropyl]amino]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-3'-deoxy-N,N-dimethyl-, 2'-(hydrogen butanedioate)

There total 4 articles about Adenosine, 3'-[[(2S)-2-(acetyloxy)-1-oxo-3-phenylpropyl]amino]-5'-O-[bis(4-methoxy phenyl)phenylmethyl]-3'-deoxy-N,N-dimethyl-, 2'-(hydrogen butanedioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 108-30-5
succinic acid anhydride

: 833447-72-6
3'-amino-3'-deoxy-3'-(L-2-acetoxy-3-phenylpropionyl)-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine

: 833447-74-8
3'-amino-3'-deoxy-3'-(L-2-acetoxy-3-phenylpropionyl)-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 24h;
DOI:10.1016/j.tet.2004.10.023

Reference yield:

: 20312-36-1
L-3-phenyllactic acid

: 833447-74-8
3'-amino-3'-deoxy-3'-(L-2-acetoxy-3-phenylpropionyl)-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 24 h / 20 °C

2: 73 percent / EDCI; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C

3: 89 percent / pyridine; triethylamine / 3 h / 20 °C

4: 57 percent / 4-(dimethylamino)pyridine; pyridine / 24 h / 20 °C

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.10.023

Reference yield:

: 33173-31-8
(S)-3-phenyl-2-acetyloxypropionic acid

: 833447-74-8
3'-amino-3'-deoxy-3'-(L-2-acetoxy-3-phenylpropionyl)-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / EDCI; N-hydroxysuccinimide / dimethylformamide / 0 - 20 °C

2: 89 percent / pyridine; triethylamine / 3 h / 20 °C

3: 57 percent / 4-(dimethylamino)pyridine; pyridine / 24 h / 20 °C

With pyridine; dmap; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.10.023