1-(2-hydroxy-2-phenylethyl)urea

Base Information

• Chemical Name: 1-(2-hydroxy-2-phenylethyl)urea
• CAS No.: 25017-52-1
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.2038
• Mol file: 25017-52-1.mol

Synonyms:Urea,(2-hydroxy-2-phenylethyl)- (9CI); Urea, (b-hydroxyphenethyl)- (7CI,8CI)

Chemical Property of 1-(2-hydroxy-2-phenylethyl)urea

Chemical Property:

• Vapor Pressure: 5.58E-06mmHg at 25°C
• Melting Point: 95 °C
• Boiling Point: 365.3°Cat760mmHg
• PKA: 13.68±0.46(Predicted)
• Flash Point: 174.8°C
• PSA: 76.34000
• Density: 1.228g/cm³
• LogP: 1.29300

Purity/Quality:

(2-hydroxy-2-phenylethyl)urea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-hydroxy-2-phenylethyl)urea

There total 5 articles about 1-(2-hydroxy-2-phenylethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) → (2-hydroxy-2-phenylethyl)urea (25017-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaOMe, MeOH, EtOH, (ii) H₂, Ni catalyst, AcOH

2: NaOAc / methanol

3: aq. HCl / Heating

With hydrogenchloride; sodium acetate; In methanol;

DOI:10.1021/jm00339a011

Reference yield:

2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → (2-hydroxy-2-phenylethyl)urea (25017-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOAc / methanol

2: aq. HCl / Heating

With hydrogenchloride; sodium acetate; In methanol;

DOI:10.1021/jm00339a011

Reference yield:

2-amino-5-phenyl-2-oxazoline (2207-50-3) → (2-hydroxy-2-phenylethyl)urea (25017-52-1)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1021/jm00339a011

upstream raw materials:

2-amino-5-phenyl-2-oxazoline

potassium cyanate

(RS)-mandelonitrile

benzaldehyde

Downstream raw materials:

1-(2,2,2-trifluoroacetyl)-3-<2-(2,2,2-trifluoroacetyloxy)-2-phenylethyl>urea

5-phenyloxazolidin-2-one

5-methyl-3-nitroso-2-oxazolidinone