2-(4-{3-[7-(trifluoromethyl)dibenzo[b,e][1,4]oxazepin-5(11H)-yl]propyl}piperazin-1-yl)ethanol

Base Information

Chemical Name:2-(4-{3-[7-(trifluoromethyl)dibenzo[b,e][1,4]oxazepin-5(11H)-yl]propyl}piperazin-1-yl)ethanol
CAS No.:27139-87-3
Molecular Formula:C₂₃H₂₈F₃N₃O₂
Molecular Weight:435.489
Hs Code.:

Synonyms:1-Piperazineethanol,4-[3-[7-(trifluoromethyl)dibenz[b,e][1,4]oxazepin-5(11)-yl]propyl]- (9CI);1-Piperazineethanol,4-[3-[7-(trifluoromethyl)dibenz[b,e][1,4]oxazepin-5(11H)-yl]propyl]- (8CI);Dibenz[b,e][1,4]oxazepine, 1-piperazineethanol deriv.

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-{3-[7-(trifluoromethyl)dibenzo[b,e][1,4]oxazepin-5(11H)-yl]propyl}piperazin-1-yl)ethanol

Chemical Property:

Vapor Pressure:6.14E-14mmHg at 25°C
Boiling Point:572.3°Cat760mmHg
Flash Point:299.9°C
Density:1.233g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(4-{3-[7-(trifluoromethyl)dibenzo[b,e][1,4]oxazepin-5(11H)-yl]propyl}piperazin-1-yl)ethanol

There total 6 articles about 2-(4-{3-[7-(trifluoromethyl)dibenzo[b,e][1,4]oxazepin-5(11H)-yl]propyl}piperazin-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27139-82-8
α,α,α-Trifluor-6'-hydroxy-m-formyltoluidin

: 27139-87-3
2-{4-[3-(7-trifluoromethyl-11H-dibenzo[b,e][1,4]oxazepin-5-yl)-propyl]-piperazin-1-yl}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: NaOMe / ethanol

2: K₂CO₃ / Cu-bronze / dimethylformamide / Heating

3: NaOH / butan-2-one / Heating

4: NaI

With sodium hydroxide; sodium methylate; potassium carbonate; sodium iodide; Cu-bronze; In ethanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00298a030

Reference yield:

: 26360-72-5
N-{2-[(2-bromobenzyl)oxy]-5-(trifluoromethyl)phenyl}formamide

: 27139-87-3
2-{4-[3-(7-trifluoromethyl-11H-dibenzo[b,e][1,4]oxazepin-5-yl)-propyl]-piperazin-1-yl}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / Cu-bronze / dimethylformamide / Heating

2: NaOH / butan-2-one / Heating

3: NaI

With sodium hydroxide; potassium carbonate; sodium iodide; Cu-bronze; In N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00298a030

Reference yield:

: 400-99-7
2-nitro-4-trifluoromethylphenol

: 27139-87-3
2-{4-[3-(7-trifluoromethyl-11H-dibenzo[b,e][1,4]oxazepin-5-yl)-propyl]-piperazin-1-yl}-ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: (i) H₂, Pd-C, EtOH, (ii) /BRN= 1209246/

2: NaOMe / ethanol

3: K₂CO₃ / Cu-bronze / dimethylformamide / Heating

4: NaOH / butan-2-one / Heating

5: NaI

With sodium hydroxide; sodium methylate; potassium carbonate; sodium iodide; Cu-bronze; In ethanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00298a030