N-(2-Hydroxyethyl)piperazine

Base Information

• Chemical Name: N-(2-Hydroxyethyl)piperazine
• CAS No.: 103-76-4
• Molecular Formula: C6H14N2O
• Molecular Weight: 130.19
• Hs Code.: 29335995
• European Community (EC) Number: 203-142-3,227-201-8
• NSC Number: 60706,38969,26884
• UNII: G7VXS31ZFP
• DSSTox Substance ID: DTXSID3021853
• Nikkaji Number: J76.692E
• Wikidata: Q27278910
• ChEMBL ID: CHEMBL3183736
• Mol file: 103-76-4.mol

Synonyms:N-(2-Hydroxyethyl)piperazine;103-76-4;1-PIPERAZINEETHANOL;1-(2-Hydroxyethyl)piperazine;2-Piperazin-1-ylethanol;2-Piperazinoethanol;Hydroxyethylpiperazine;2-(piperazin-1-yl)ethan-1-ol;1-Piperazinethanol;2-(1-Piperazinyl)ethanol;2-Hydroxyethylpiperazine;2-(piperazin-1-yl)ethanol;USAF DO-22;4-(2-Hydroxyethyl)piperazine;Ethanol, 2-(1-piperazinyl)-;Piperazine-1-ethanol;N-(beta-Hydroxyethyl)piperazine;1-(beta-Hydroxyethyl)piperazine;2-Piperazin-1-yl-ethanol;MFCD00005970;NSC 26884;1-(2-hydroxyethyl)-piperazine;CCRIS 6687;1-(.beta.-Hydroxyethyl)piperazine;2-hydroxyethyl piperazine;EINECS 203-142-3;UNII-G7VXS31ZFP;G7VXS31ZFP;N-(Hydroxyethyl)piperazine;BRN 0104361;AI3-25357;(.beta.-Hydroxyethyl)piperazine;DTXSID3021853;N-(.beta.-Hydroxyethyl)piperazine;N-beta-HYDROXYETHYLPIPERAZINE;NSC-26884;NSC-38969;NSC-60706;WLN: T6M DNTJ D2Q;5-23-01-00406 (Beilstein Handbook Reference);N-(2-Hydroxyethyl)piperazine(1-Piperazineethanol);1-(ss-Hydroxyethyl)Piperazine;DTXCID401853;C6H14N2O.2ClH;CAS-103-76-4;C6-H14-N2-O.2Cl-H;5712-71-0;1-(hydroxyethyl)piperazine;piperazine ethanol;NSC26884;N-piperazine ethanol;1-piperazine ethanol;1-piperazine-ethanol;hydroxylethylpiperazine;2-piperazinyl-ethanol;hydroxyethyl piperazine;n-hydroxyethylpiperazine;2-hydroxyethylpiperizine;2-hydroxylethylpiperazine;N-hydroxyethyl-piperazine;4-hydroxyethyl-piperazine;n-2-hydroxyethylpiperazine;2-piperazin 1-yl-ethanol;2-piperazin-1-yl ethanol;(2-Hydroxyethyl)piperazine;2-piperazine-1-yl-ethanol;4-N-hydroxyethyl-piperazine;SCHEMBL1194;1-(2-hydoxyethyl)piperazine;1-(2-hydroxyethyl)piperazin;1(2-hydroxyethyl)-piperazine;1-(2-hydroxyethyl)piperizine;2-(piperazin-1-yl) ethanol;2-(piperazin-1-yl)-ethanol;N-beta-hydroxyethyl-piperazine;1-(2-hydroxyethyl)-piperazin;1-beta-hydroxyethyl piperazine;2-(1-piperazinyl)-l-ethanol;N-(2-hydroxy-ethyl)piperazine;N-(2-hydroxyethyl)-piperazine;1-(2 -hydroxyethyl)piperazine;1-(2'-hydroxyethyl)piperazine;1-(2-hydroxyethyl) piperazine;2-(1-piperazinyl)-1-ethanol;4-(2-Hydroxyethyl)-piperazine;1-(2-hydroxylethyl)-piperazine;CHEMBL3183736;1-(2-Hydroxy-ethyl)-piperazine;4-(2-hydroxy-ethyl) piperazine;1-(beta-hydroxyethyl)-piperazine;NSC38969;NSC60706;STR01986;Tox21_201974;Tox21_302881;STL193986;1-(2-Hydroxyethyl)piperazine, 98%;1-Hydroxy-2-(piperazin-1-yl)ethane;AKOS000120230;AC-2946;CS-W020134;LF-0553;SB11221;NCGC00249142-01;NCGC00256344-01;NCGC00259523-01;BP-30097;SY003404;LS-112025;A1877;AM20070679;FT-0608268;FT-0669365;P0812;EN300-20181;P16516;W-108839;Q27278910;F2190-0344;Z104477190;1-(2-Hydroxyethyl)piperazine, Vetec(TM) reagent grade, 98%

Chemical Property of N-(2-Hydroxyethyl)piperazine

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow oily liquid
• Vapor Pressure: 0.0322mmHg at 25°C
• Melting Point: -38.5 °C
• Refractive Index: n20/D 1.506(lit.)
• Boiling Point: 245 °C at 760 mmHg
• PKA: 14.96±0.10(Predicted)
• Flash Point: 101.9 °C
• PSA: 35.50000
• Density: 1.012 g/cm³
• LogP: -0.84940
• Storage Temp.: Store below +30°C.
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: MISCIBLE
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 130.110613074
• Heavy Atom Count: 9
• Complexity: 71.5

Purity/Quality:

99.5%min. ^*data from raw suppliers

N-?(2-?Hydroxyethyl)?piperazine(1-Piperazineethanol) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41-38
• Safety Statements: 26-36/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Piperazines
• Canonical SMILES: C1CN(CCN1)CCO
• Uses: 1-(2-Hydroxyethyl)piperazine is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents. 1-Piperazineethanol is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents.

Technology Process of N-(2-Hydroxyethyl)piperazine

There total 40 articles about N-(2-Hydroxyethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-[(3-methyl-2-butenyl)oxycarbonyl]-1-(2-hydroxyethyl)piperazine (161742-25-2) → 1-(2-hydroxyethyl)piperazine (103-76-4)

Guidance literature:

With diethylamine; Pd⁽⁰⁾ (in situ from Pd(OAc)2 and m.sulfonated triphenylphosphine); In water; acetonitrile; for 0.25h; 5 molpercent catalyst;

DOI:10.1016/S0040-4039(00)78497-8

Reference yield: 100.0%

2-(4-allyl-piperazin-1-yl)-ethanol (27612-67-5) → 1-(2-hydroxyethyl)piperazine (103-76-4)

Guidance literature:

With Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/0040-4039(95)00003-U

Reference yield: 95.0%

oxirane (75-21-8,99932-75-9) + piperazine (110-85-0) → 1-(2-hydroxyethyl)piperazine (103-76-4)

Guidance literature:

In various solvent(s); at 40 ℃; for 0.5h;

upstream raw materials:

oxirane

piperazine

4-[(3-methyl-2-butenyl)oxycarbonyl]-1-(2-hydroxyethyl)piperazine

2-(4-allyl-piperazin-1-yl)-ethanol

Downstream raw materials:

2-{4-[(octahydro-pyrido[2,1-c][1,4]oxazepin-4-yl)-phenyl-methyl]-piperazin-1-yl}-ethanol

7-Hydroxyperphenazin

8-Hydroxyperphenazin

7,8-dihydroxyperphenazine

Refernces

• 1、 -. "Synthesis method for co-production of N-hydroxyethyl piperazine and N-ethyl piperazine". Paragraph 0008; 0029-0087. . Retrieved 2021/03/11.
• 2、 Borlinghaus, Niels,Gergel, Sebastian,Nestl, Bettina M.. "Biocatalytic Access to Piperazines from Diamines and Dicarbonyls". . p. 3727 - 3732. Retrieved 2018/04/14.