4-Ethylpyridin-3-OL

Base Information

• Chemical Name: 4-Ethylpyridin-3-OL
• CAS No.: 83431-03-2
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.155
• DSSTox Substance ID: DTXSID90510264
• Nikkaji Number: J1.771.179B
• Wikidata: Q82368440
• Mol file: 83431-03-2.mol

Synonyms:4-ETHYLPYRIDIN-3-OL;83431-03-2;3-PYRIDINOL, 4-ETHYL-;4-ETHYL-3-PYRIDINOL;SCHEMBL13625817;DTXSID90510264;MB12325;A1-30460

Chemical Property of 4-Ethylpyridin-3-OL

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(C=NC=C1)O

Technology Process of 4-Ethylpyridin-3-OL

There total 1 articles about 4-Ethylpyridin-3-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

furo<2,3-c>pyridine (19539-50-5) → 4-ethyl-3-hydroxypyridine (83431-03-2) + 4-ethynyl-3-pyridinol (142503-06-8) + 4-vinyl-3-pyridinol (465519-16-8)

Guidance literature:

With ammonia; sodium; In diethyl ether; for 0.5h;

DOI:10.1002/jhet.5570390215

Reference yield: 71.0%

4-ethyl-3-hydroxypyridine (83431-03-2) + 3-bromo-1-phenyl-1-propenyl bromide (4392-24-9) → 1-cinnamyl-4-ethyl-3-hydroxypyridin-1-ium bromide

Guidance literature:

In acetone; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201800365

Reference yield:

4-ethyl-3-hydroxypyridine (83431-03-2) → (1R,3R,4R,5R)-4-allyl-8-cinnamyl-3-ethyl-8-azaspiro[bicyclo[3.2.1]octane-6,2'-[1,3]dithiolan]-2-one

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetone / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.2: 0.33 h / -10 °C / Inert atmosphere

2.3: 2 h / -10 °C / Inert atmosphere

3.1: copper(I) bromide dimethylsulfide complex; lithium chloride / tetrahydrofuran / 0.17 h / -78 °C / Schlenk technique; Inert atmosphere

With copper(I) bromide dimethylsulfide complex; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1002/chem.201800365

upstream raw materials:

furo<2,3-c>pyridine