19539-50-5

Basic information

• Product Name: Furo[2,3-c]pyridine
• Synonyms: Furo[2,3-c]pyridine
• CAS NO: 19539-50-5
• Molecular Formula: C₇H₅NO
• Molecular Weight: 119.122
• Mol File: 19539-50-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 198℃
• Flash Point: 78℃
• Appearance: /
• Density: 1.196
• Vapor Pressure: 0.52mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Furo[2,3-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-c]pyridine(19539-50-5)
• EPA Substance Registry System: Furo[2,3-c]pyridine(19539-50-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 19539-50-5(Hazardous Substances Data)

Usage

General Description

Furo[2,3-c]pyridine is a heterocyclic compound with the chemical formula C8H6N2O. It consists of a furan ring fused to a pyridine ring, and it is commonly used as a building block in the synthesis of various organic compounds. Furo[2,3-c]pyridine has potential applications in pharmaceuticals, agrochemicals, and materials science due to its diverse reactivity and structural versatility. It is an aromatic compound with a relatively stable structure, making it an important component in the development of new and complex organic molecules. Overall, furo[2,3-c]pyridine is a valuable and versatile chemical building block with potential for various applications in the field of organic chemistry.

InChI:InChI=1/C7H5NO/c1-3-8-5-7-6(1)2-4-9-7/h1-5H

Upstream product

• 18342-97-7 ethyl 3-hydroxyisonicotinate 
• 1219102-40-5 acetic acid 4-bromo-pyridin-3-yl ester 
• 161417-28-3 4-bromo-3-hydroxypyridine 
• 34259-86-4 1-benzenesulfonyl-piperidin-4-one 
• 1334308-13-2 6-benzenesulfonyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine 
• 1334308-12-1 6-benzenesulfonyl-5,6,7,7a-tetrahydro-4H-furo[2,3-c]pyridin-2-one 
• 1228187-72-1 C₁₅H₁₉NO₄S 
• 1228187-59-4 (1-benzenesulfonyl-1,2,3-6-tetrahydropyridin-4-yl)-acetic acid ethyl ester 
• 289473-47-8 3-acetoxy-4-[2-(trimethylsilyl)ethynyl]pyridine 
• 109-72-8 n-butyllithium 
• 1219101-85-5 2-trimethylsilylfuro[2,3-c]pyridine 
• 84400-98-6 furo<2,3-c>pyridin-7(6H)-one 
• 106531-51-5 Furo<2,3-c>pyridin-3(2H)-one hydrochloride 
• 106531-50-4 Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate 

Downstream Products

• 92404-66-5 3-bromofuro<2,3-c>pyridine 
• 112372-06-2 furo<2,3-c>pyridine-2-carboxaldehyde 
• 142502-97-4 2-phenylthiofuro<2,3-c>pyridine 
• 181526-20-5 Furo[2,3-c]pyridine 6-oxide 
• 83431-03-2 4-ethyl-3-hydroxypyridine 
• 142503-06-8 4-ethynyl-3-pyridinol 
• 465519-16-8 4-vinyl-3-pyridinol 
• 193605-52-6 5-chloro-2,3-dihydrofuro[2,3-c]pyridine 
• 193605-63-9 7-cyano-2,3-dihydrofuro[2,3-c]pyridine 
• 193605-62-8 5-cyano-2,3-dihydrofuro[2,3-c]pyridine 
• 188939-35-7 7-Benzyl-furo[2,3-c]pyridine 
• 188939-38-0 4-Furo[2,3-c]pyridin-7-ylmethyl-benzonitrile 
• 188939-37-9 7-(4-Methoxy-benzyl)-furo[2,3-c]pyridine 
• 188939-32-4 7-[1-Phenyl-meth-(E)-ylidene]-7H-furo[2,3-c]pyridine-6-carboxylic acid isopropyl ester 

Relevant articles and documents

FACTOR XIIA INHIBITORS

This invention relates to compoundsof formula (I)and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

Synthesis of furo[2,3-c]pyridine

A new synthetic strategy toward furo[2,3-c]pyridine (1) starting with N-benzenesulfonylpiperidin-4-one (2) in good yield is described. A synthesis of azasuger analog 9 is also prepared. The Japan Institute of Heterocyclic Chemistry.

Furopyridines. XXIV [1]. Nitration, Chlorination, Acetoxylation and Cyanation of 2,3-Dihydrofuro[2,3-b]-, -[3,2-b]-, -[2,3-c]- and -[3,2-c]pyridine N-Oxides

Nitration of 2,3-dihydrofuro[3,2-b]- N-oxide 3b and -[2,3-c] pyridine N-oxide 3c afforded the nitropyridine compounds 4b, 5b and 6 from 3b and 4c, 5c, 5′c and 7 from 3c, while -[2,3-b]- N-oxide 3a and -[3,2-c]pyridine N-oxide 3d did not give the nitro compound. Chlorination of 3b and 3c with phosphorus oxychloride yielded mainly the chloropyridine derivatives 15b, 15′b from 3b and 15c and 15′c from 3c, whereas 3a and 3d gave pyridine derivatives formed through fission of the 1-2 ether bond of the furopyridines 13a, 14 and 13d. Acetoxylation of 3b and 3c gave 3-acetoxy derivatives 18b and 18c and the parent compound 1b and 1c. Acetoxylation of 3a yielded compounds formed through fission of the 1-2 bond 16 and 17 and 3d gave furopyridones 19 and 19′. Cyanation of 3b and 3c yielded mainly the cyanopyridine compounds 20b, 20c and 20′c. Cyanation of 3a and 3d gave the cyanopyridine compounds 20a, 20d and 20′d accompanying formation of the pyridine derivatives 21a, 21d and 21′d.