2-Naphthalenecarboxylic acid, 4-hydroxy-5,6,8-trimethoxy-, ethyl ester

Base Information

Chemical Name:2-Naphthalenecarboxylic acid, 4-hydroxy-5,6,8-trimethoxy-, ethyl ester
CAS No.:834866-83-0
Molecular Formula:C₁₆H₁₈O₆
Molecular Weight:306.315
Hs Code.:
DSSTox Substance ID:DTXSID30479604
Nikkaji Number:J2.569.832K
Wikidata:Q82313724

Synonyms:834866-83-0;2-Naphthalenecarboxylic acid, 4-hydroxy-5,6,8-trimethoxy-, ethyl ester;DTXSID30479604;2-Naphthalenecarboxylic acid,4-hydroxy-5,6,8-trimethoxy-,ethyl ester

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Chemical Property of 2-Naphthalenecarboxylic acid, 4-hydroxy-5,6,8-trimethoxy-, ethyl ester

Chemical Property:

Vapor Pressure:1.92E-10mmHg at 25°C
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:306.11033829
Heavy Atom Count:22
Complexity:374

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC2=C(C(=C1)O)C(=C(C=C2OC)OC)OC

Technology Process of 2-Naphthalenecarboxylic acid, 4-hydroxy-5,6,8-trimethoxy-, ethyl ester

There total 3 articles about 2-Naphthalenecarboxylic acid, 4-hydroxy-5,6,8-trimethoxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 25936-85-0
ethyl 4-acetoxy-5,6,8-trimethoxy-2-naphthoate

: 834866-83-0
4-hydroxy-5,6,8-trimethoxynaphthalene-2-carboxylic acid ethyl ester

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 0.166667h;
DOI:10.1016/j.tet.2004.11.010

Reference yield:

: 4460-86-0,14374-62-0
asaraldehyde

: 834866-83-0
4-hydroxy-5,6,8-trimethoxynaphthalene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / t-BuOK / 2-methyl-propan-2-ol / 0.67 h / Heating

2: 81 percent / Ac₂O / 0.75 h / Heating

3: 84 percent / aq. NaOH / ethanol / 0.17 h / 20 °C

With sodium hydroxide; potassium tert-butylate; acetic anhydride; In ethanol; tert-butyl alcohol;
DOI:10.1016/j.tet.2004.11.010

Reference yield:

: 367248-67-7
(E)-3-ethoxycarbonyl-4-(2,4,5-trimethoxyphenyl)but-3-enoic acid

: 834866-83-0
4-hydroxy-5,6,8-trimethoxynaphthalene-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Ac₂O / 0.75 h / Heating

2: 84 percent / aq. NaOH / ethanol / 0.17 h / 20 °C

With sodium hydroxide; acetic anhydride; In ethanol;
DOI:10.1016/j.tet.2004.11.010