3alpha-Dihydroprogesterone

Base Information

Chemical Name:3alpha-Dihydroprogesterone
CAS No.:25680-68-6
Molecular Formula:C21H32 O2
Molecular Weight:316.484
Hs Code.:
UNII:6U8M6JFV3W
DSSTox Substance ID:DTXSID201032983,DTXSID50948564
Nikkaji Number:J322.205E
Wikipedia:3%CE%B1-Dihydroprogesterone
Wikidata:Q21099649
ChEMBL ID:CHEMBL288508
Mol file:25680-68-6.mol

Synonyms:3 alpha-hydroxy-4-pregnen-20-one;3-dihydroprogesterone;3-hydroxypregn-4-en-20-one;3-hydroxypregn-4-en-20-one, (3beta)-isomer;3alpha-dihydroprogesterone;3alphaHP

Suppliers and Price of 3alpha-Dihydroprogesterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 21 raw suppliers

Chemical Property of 3alpha-Dihydroprogesterone

Chemical Property:

Vapor Pressure:8.76E-10mmHg at 25°C
Melting Point:124 - 128°C
Boiling Point:444.9°Cat760mmHg
PKA:14.37±0.70(Predicted)
Flash Point:189.6°C
PSA：37.30000
Density:1.09g/cm³
LogP:4.51530
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:316.240230259
Heavy Atom Count:23
Complexity:550

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1CCC2C1(CCC3C2CCC4=CC(CCC34C)O)C
Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C[C@@H](CC[C@]34C)O)C
Uses 3α-Hydroxy Progesterone is a metabolite of Progesterone (P755900), a steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Technology Process of 3alpha-Dihydroprogesterone

There total 18 articles about 3alpha-Dihydroprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 3α-benzoyloxypregn-4-en-20-one

: 25680-68-6
3α-hydroxy-4-pregnen-20-one

Guidance literature:: With potassium hydroxide; In methanol; at 60 ℃; for 2.5h;
DOI:10.1007/s11172-020-2797-4

Reference yield: 40.0%

: 57-83-0
Progesterone

: 566-66-5,25680-68-6,104528-39-4
4-pregnen-3-ol-20-one

: 15780-23-1
pregn-4-ene-3,20-diol

Guidance literature:: With zinc(II) tetrahydroborate; In diethyl ether; for 1h; Product distribution; Heating; other solvents and reducing agents also investigated;
DOI:10.1016/0040-4020(82)80246-9

Reference yield: 20.0%

: 57-83-0
Progesterone

: 15114-79-1
20-hydroxy-Δ⁴-progest-3-one

: 566-66-5,25680-68-6,104528-39-4
4-pregnen-3-ol-20-one

: 15780-23-1
pregn-4-ene-3,20-diol

Guidance literature:: With zinc(II) tetrahydroborate; In acetonitrile; for 26h; Mechanism; Ambient temperature;
DOI:10.1016/0040-4020(82)80090-2