6-Chloro-3-Fluoro-2-hydroxyquinoline

Base Information

Chemical Name:6-Chloro-3-Fluoro-2-hydroxyquinoline
CAS No.:834883-95-3
Molecular Formula:C₉H₅ClFNO
Molecular Weight:197.596
Hs Code.:
DSSTox Substance ID:DTXSID90479781
Nikkaji Number:J2.136.909H
Wikidata:Q82314010
Mol file:834883-95-3.mol

Synonyms:6-Chloro-3-Fluoro-2-hydroxyquinoline;834883-95-3;6-CHLORO-3-FLUORO-1H-QUINOLIN-2-ONE;DTXSID90479781;AKOS024263629;FT-0704162

Suppliers and Price of 6-Chloro-3-Fluoro-2-hydroxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-Chloro-3-Fluoro-2-hydroxyquinoline

Chemical Property:

PSA：33.12000
LogP:2.73290
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:197.0043696
Heavy Atom Count:13
Complexity:266

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1Cl)C=C(C(=O)N2)F

Technology Process of 6-Chloro-3-Fluoro-2-hydroxyquinoline

There total 2 articles about 6-Chloro-3-Fluoro-2-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-chloro-phenyl)-2-fluoro-3-methoxy-acrylamide

: 834883-95-3
6-chloro-3-fluoroquinol-2(1H)-one

Guidance literature:: With sulfuric acid; at 50 ℃; for 5h;
DOI:10.1016/j.tet.2004.10.053

Reference yield:

: 106-47-8
4-chloro-aniline

: 834883-95-3
6-chloro-3-fluoroquinol-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C

2: 89.9 g / sulfuric acid / 5 h / 50 °C

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2004.10.053