2-Bromo-6-chloro-3-fluoroquinoline

Base Information

Chemical Name:2-Bromo-6-chloro-3-fluoroquinoline
CAS No.:834884-00-3
Molecular Formula:C₉H₄BrClFN
Molecular Weight:260.493
Hs Code.:
DSSTox Substance ID:DTXSID00479737
Nikkaji Number:J2.136.903I
Mol file:834884-00-3.mol

Synonyms:2-Bromo-6-chloro-3-fluoroquinoline;834884-00-3;DTXSID00479737;AKOS024263620;FT-0766058

Suppliers and Price of 2-Bromo-6-chloro-3-fluoroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Bromo-6-chloro-3-fluoroquinoline

Chemical Property:

PSA：12.89000
LogP:3.78980
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:258.91997
Heavy Atom Count:13
Complexity:193

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=NC(=C(C=C2C=C1Cl)F)Br

Technology Process of 2-Bromo-6-chloro-3-fluoroquinoline

There total 3 articles about 2-Bromo-6-chloro-3-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 834883-95-3
6-chloro-3-fluoroquinol-2(1H)-one

: 834884-00-3
2-bromo-6-chloro-3-fluoroquinoline

Guidance literature:: With phosphorus(V) oxybromide; at 190 ℃; for 0.5h;
DOI:10.1016/j.tet.2004.10.053

Reference yield:

: 106-47-8
4-chloro-aniline

: 834884-00-3
2-bromo-6-chloro-3-fluoroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C

2: 89.9 g / sulfuric acid / 5 h / 50 °C

3: 78 percent / phosphoric tribromide / 0.5 h / 190 °C

With n-butyllithium; sulfuric acid; phosphorus(V) oxybromide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2004.10.053

Reference yield:

: N-(4-chloro-phenyl)-2-fluoro-3-methoxy-acrylamide

: 834884-00-3
2-bromo-6-chloro-3-fluoroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 89.9 g / sulfuric acid / 5 h / 50 °C

2: 78 percent / phosphoric tribromide / 0.5 h / 190 °C

With sulfuric acid; phosphorus(V) oxybromide;
DOI:10.1016/j.tet.2004.10.053