8-Bromo-3-fluoro-2-hydroxyquinoline

Base Information

Chemical Name:8-Bromo-3-fluoro-2-hydroxyquinoline
CAS No.:834883-96-4
Molecular Formula:C₉H₅BrFNO
Molecular Weight:242.047
Hs Code.:2933499090
DSSTox Substance ID:DTXSID50479782
Nikkaji Number:J2.136.901B
Mol file:834883-96-4.mol

Synonyms:834883-96-4;8-Bromo-3-fluoro-2-hydroxyquinoline;8-Bromo-3-fluoroquinolin-2-ol;8-bromo-3-fluoroquinolin-2(1H)-one;8-BROMO-3-FLUORO-1H-QUINOLIN-2-ONE;DTXSID50479782;AKOS024263521;AS-62912;CS-0068200;FT-0724369;8-bromo-3-fluoro-1,2-dihydroquinolin-2-one;D72313

Suppliers and Price of 8-Bromo-3-fluoro-2-hydroxyquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Apolloscientific
8-Bromo-3-fluoroquinolin-2(1H)-one >98%
100mg
$ 519.00

Ambeed
8-Bromo-3-fluoroquinolin-2-ol 95%
1g
$ 390.00

Ambeed
8-Bromo-3-fluoroquinolin-2-ol 95%
250mg
$ 156.00

Ambeed
8-Bromo-3-fluoroquinolin-2-ol 95%
100mg
$ 104.00

Total 5 raw suppliers

Chemical Property of 8-Bromo-3-fluoro-2-hydroxyquinoline

Chemical Property:

Melting Point:202-204 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
Boiling Point:387.1±42.0 °C(Predicted)
PKA:8.74±0.70(Predicted)
PSA：33.12000
Density:1.77±0.1 g/cm3(Predicted)
LogP:2.84200
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:240.95385
Heavy Atom Count:13
Complexity:266

Purity/Quality:

99%, ^*data from raw suppliers

8-Bromo-3-fluoroquinolin-2(1H)-one >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C(=C1)Br)NC(=O)C(=C2)F

Technology Process of 8-Bromo-3-fluoro-2-hydroxyquinoline

There total 2 articles about 8-Bromo-3-fluoro-2-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(2-bromo-phenyl)-2-fluoro-3-methoxy-acrylamide

: 834883-96-4
8-bromo-3-fluoroquinol-2(1H)-one

Guidance literature:: With sulfuric acid; at 50 ℃; for 5h;
DOI:10.1016/j.tet.2004.10.053

Reference yield:

: 615-36-1
2-bromoaniline

: 834883-96-4
8-bromo-3-fluoroquinol-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: butyllithium / tetrahydrofuran; hexane / 1 h / 25 °C

2: 71.4 g / sulfuric acid / 5 h / 50 °C

With n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2004.10.053