Phosphinic amide, N-[[2-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-1-meth ylcyclopropyl]phenylmethyl]-P,P-diphenyl-

Base Information

Chemical Name:Phosphinic amide, N-[[2-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-1-meth ylcyclopropyl]phenylmethyl]-P,P-diphenyl-
CAS No.:834889-17-7
Molecular Formula:C42H48NO2PSi
Molecular Weight:657.908
Hs Code.:

Phosphinic amide,
N-[[2-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-1-meth
ylcyclopropyl]phenylmethyl]-P,P-diphenyl-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phosphinic amide, N-[[2-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-1-meth ylcyclopropyl]phenylmethyl]-P,P-diphenyl-

Chemical Property:

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Technology Process of Phosphinic amide, N-[[2-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-1-meth ylcyclopropyl]phenylmethyl]-P,P-diphenyl-

There total 8 articles about Phosphinic amide, N-[[2-[(1R)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylethyl]-1-meth ylcyclopropyl]phenylmethyl]-P,P-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 833487-53-9
(1SR,2E,4R)-N-[5-(tert-butyldiphenylsilanyloxy)-2,4-dimethyl-1-phenylpent-2-enyl]-P,P-diphenylphosphinamide

: 75-11-6
diiodomethane

: 98837-46-8,67764-52-7
P,P-diphenyl-N-(phenylmethylene)phosphinic amide

: 834889-17-7
N-{(SR)-[(1RS,2SR)-2-{(1R)-2-[(tert-butyldiphenylsilanyl)oxy]-1-methylethyl}-1-methylcyclopropyl](phenyl)methyl}-P,P-diphenylphosphinamide

Guidance literature:: Multistep reaction;
DOI:10.1021/ol0477529

Reference yield: 60.0%

: 75-11-6
diiodomethane

: 98837-46-8,67764-52-7
P,P-diphenyl-N-(phenylmethylene)phosphinic amide

: 194610-24-7
(4R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-pentyne

: 834889-17-7
C₄₂H₄₈NO₂PSi

Guidance literature:: Multistep reaction;
DOI:10.1002/adsc.200505171

Reference yield:

: 92817-88-4
(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

: 834889-17-7
N-{(SR)-[(1RS,2SR)-2-{(1R)-2-[(tert-butyldiphenylsilanyl)oxy]-1-methylethyl}-1-methylcyclopropyl](phenyl)methyl}-P,P-diphenylphosphinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / zinc dust; PPh₃ / CH₂Cl₂ / 25 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: Cp₂ZrHCl / tetrahydrofuran / 0.33 h / 20 °C

3.2: Me₂Zn / tetrahydrofuran; toluene / -78 - 20 °C

3.3: 59 percent / tetrahydrofuran; toluene / 5 h / Heating

With Schwartz's reagent; n-butyllithium; triphenylphosphine; zinc; In tetrahydrofuran; hexane; dichloromethane; 1.1: Corey-Fuchs reaction;
DOI:10.1021/ol0477529