Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl-

Base Information

Chemical Name:Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl-
CAS No.:194610-24-7
Molecular Formula:C22H28OSi
Molecular Weight:336.549
Hs Code.:
DSSTox Substance ID:DTXSID60441238
Nikkaji Number:J1.172.323C
Mol file:194610-24-7.mol

Synonyms:Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl-;194610-24-7;DTXSID60441238;(4R)-4-Methyl-5-(tert-butyldiphenylsiloxy)-2-pentyne

Suppliers and Price of Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl-

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:336.190942047
Heavy Atom Count:24
Complexity:420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC#CC(C)CO[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C
Isomeric SMILES:CC#C[C@@H](C)CO[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C

Technology Process of Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl-

There total 4 articles about Silane, (1,1-dimethylethyl)[[(2R)-2-methyl-3-pentynyl]oxy]diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 194610-23-6
(R)-tert-butyl((4,4-dibromo-2-methylbut-3-en-1-yl)oxy)diphenylsilane

: 74-88-4
methyl iodide

: 194610-24-7
(4R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-pentyne

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃;
DOI:10.1248/cpb.47.1288

Reference yield:

: 92817-88-4
(2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal

: 194610-24-7
(4R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-pentyne

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / zinc dust; PPh₃ / CH₂Cl₂ / 25 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; triphenylphosphine; zinc; In tetrahydrofuran; hexane; dichloromethane; 1.1: Corey-Fuchs reaction;
DOI:10.1021/ol0477529

Reference yield:

: 95514-03-7
(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

: 194610-24-7
(4R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-pentyne

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / DIBAL / CH₂Cl₂; hexane / 1.5 h / -78 °C

2.1: 87 percent / zinc dust; PPh₃ / CH₂Cl₂ / 25 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

3.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; diisobutylaluminium hydride; triphenylphosphine; zinc; In tetrahydrofuran; hexane; dichloromethane; 2.1: Corey-Fuchs reaction;
DOI:10.1021/ol0477529