Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]-

Base Information

Chemical Name:Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]-
CAS No.:834895-45-3
Molecular Formula:C29H24FNO
Molecular Weight:421.514
Hs Code.:
DSSTox Substance ID:DTXSID70479365
Nikkaji Number:J2.132.229F

Synonyms:834895-45-3;Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]-;DTXSID70479365

Suppliers and Price of Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]-

Chemical Property:

XLogP3:7.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:421.18419255
Heavy Atom Count:32
Complexity:668

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)C2=C(C=C(C=C2)C3(C=CC4=C(O3)C=CC5=CC=CC=C54)C6=CC=CC=C6)F

Technology Process of Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]-

There total 4 articles about Pyrrolidine, 1-[2-fluoro-4-(3-phenyl-3H-naphtho[2,1-b]pyran-3-yl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 834895-59-9
1-(3-fluoro-4-pyrrolidinophenyl)-1-phenylprop-2-yn-1-ol

: 135-19-3
β-naphthol

: 834895-45-3
3-(3-fluoro-4-pyrrolidinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran

Guidance literature:: With aluminum oxide; In toluene; for 1.5h; Heating;
DOI:10.1016/j.tet.2004.10.069

Reference yield:

: 314040-09-0
3-fluoro-4-pyrrolidinobenzophenone

: 834895-45-3
3-(3-fluoro-4-pyrrolidinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -10 °C

1.2: hexane; tetrahydrofuran / 3 h / 0 - 20 °C

2.1: potassium hydroxide / methanol / 0.25 h / 0 - 20 °C

3.1: 68 percent / acidic alumina / toluene / 1.5 h / Heating

With aluminum oxide; potassium hydroxide; n-butyllithium; In tetrahydrofuran; methanol; hexane; toluene;
DOI:10.1016/j.tet.2004.10.069

Reference yield:

: 1-(3-fluoro-4-pyrrolidin-1-yl-phenyl)-1-phenyl-3-trimethylsilanyl-prop-2-yn-1-ol

: 834895-45-3
3-(3-fluoro-4-pyrrolidinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / methanol / 0.25 h / 0 - 20 °C

2: 68 percent / acidic alumina / toluene / 1.5 h / Heating

With aluminum oxide; potassium hydroxide; In methanol; toluene;
DOI:10.1016/j.tet.2004.10.069