2-Naphthol

Base Information

• Chemical Name: 2-Naphthol
• CAS No.: 135-19-3
• Deprecated CAS: 860440-31-9
• Molecular Formula: C10H8O
• Molecular Weight: 144.173
• Hs Code.: 2907151000
• European Community (EC) Number: 205-182-7
• ICSC Number: 0719
• NSC Number: 758883,2044
• UN Number: 3077
• UNII: P2Z71CIK5H
• DSSTox Substance ID: DTXSID5027061
• Nikkaji Number: J2.530E
• Wikipedia: 2-Naphthol
• Wikidata: Q949232
• NCI Thesaurus Code: C81517
• Metabolomics Workbench ID: 41998
• ChEMBL ID: CHEMBL14126
• Mol file: 135-19-3.mol

Synonyms:2-hydroxynaphthalene;2-naphthol;2-naphthol, (1+);2-naphthol, 1,4,5,8-(14)C4-labeled;2-naphthol, 7-(14)C-labeled;2-naphthol, 8-(14)C-labeled;2-naphthol, bismuth salt;2-naphthol, magnesium salt;2-naphthol, potassium salt;2-naphthol, sodium salt;2-naphthol, titanium(4+) salt;beta-naphthol

Chemical Property of 2-Naphthol

Chemical Property:

• Appearance/Colour: broken white shiny flakes or white powder
• Vapor Pressure: 0.00162mmHg at 25°C
• Melting Point: 120-122 °C(lit.)
• Refractive Index: 1.677
• Boiling Point: 285.499 °C at 760 mmHg
• Flash Point: 144.002 °C
• PSA: 20.23000
• Density: 1.182 g/cm³
• LogP: 2.54540
• Water Solubility.: 1 g/L (20℃)
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 144.057514874
• Heavy Atom Count: 11
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn:Harmful;;
• Statements: R20/22:; R50:
• Safety Statements: S24/25:; S61:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Naphthols
• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)O
• Inhalation Risk: A harmful concentration of airborne particles can be reached quickly when dispersed.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys, blood and eyes. This may result in kidney impairment, anaemia and lens opacities.

Technology Process of 2-Naphthol

There total 503 articles about 2-Naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

→ titanium dioxide (13463-67-7) + β-naphthol (135-19-3)

Guidance literature:

Reference yield: 72.0%

anthranilic acid amide (28144-70-9,88-68-6) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) → 4-Hydroxyquinazoline (491-36-1) + 2-(2-hydroxynaphthalen-1-yl)-4(3H)-quinazolinone (106910-74-1) + β-naphthol (135-19-3)

Guidance literature:

With sodium hydrogensulfide; In N,N-dimethyl acetamide; at 150 ℃; for 2h;

Reference yield: 69.0%

2-(2-hydroxynaphthalene-1-yl)-2,3-dihydroquinazolin-4(1H)-one (106910-75-2) → 4-Hydroxyquinazoline (491-36-1) + β-naphthol (135-19-3)

Guidance literature:

In 1,2-dichloro-benzene; for 6h; Heating;

upstream raw materials:

methanol

benzylidene-1,1'-bis(2-naphthol)

sodium methylate

3-methyl-1-phenylpyrazolin-5(4H)-one

Downstream raw materials:

2-Methoxynaphthalene

1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol

1-piperidin-1-ylmethyl-naphthalen-2-ol

N-(2-naphthyl)piperidine

Refernces

• 1、 El Sayed, Sameh,De La Torre, Cristina,Santos-Figueroa, Luis E.,Martinez-Manez, Ramon,Sancenon, Felix,Orzaez, Mar,Costero, Ana M.,Parra, Margarita,Gil, Salvador. "2,4-dinitrophenyl ether-containing chemodosimeters for the selective and sensitive in vitro and in vivo detection of hydrogen sulfide". . p. 244 - 254. Retrieved 2015.
• 2、 Hekal, Mohamed H.,Abu El-Azm, Fatma S. M.,Samir, Sandy S.. "An efficient approach for the synthesis and antimicrobial evaluation of some new benzocoumarins and related compounds". . p. 2175 - 2186. Retrieved 2021.
• 3、 Hanessian, Stephen,Delorme, Daniel,Dufresne, Yves. "MILD CLEAVAGE OF METHOXYMETHYL (MOM) ESTERS WITH TRIMETHYLSILYLBROMIDE". . p. 2515 - 2518. Retrieved 1984.
• 4、 Iyer, Aditya,Chandra, Anil,Swaminathan, Rajaram. "Hydrolytic enzymes conjugated to quantum dots mostly retain whole catalytic activity". . p. 2935 - 2943. Retrieved 2014.
• 5、 Jadhav, Vinod H.,Kim, Jin Gwan,Jeong, Hyeon Jin,Kim, Dong Wook. "Nucleophilic Hydroxylation in Water Media Promoted by a Hexa-Ethylene Glycol-Bridged Dicationic Ionic Liquid". . p. 7275 - 7280. Retrieved 2015.
• 6、 Ochocinska, Agata,Siegbahn, Anna,Ellervik, Ulf. "HCl/DMF for enhanced chemoselectivity in catalytic hydrogenolysis reactions". . p. 5200 - 5202. Retrieved 2010.
• 7、 Feng, Xuechun,Liu, Nannan. "Functional Analyses of House Fly Carboxylesterases Involved in Insecticide Resistance". . . Retrieved 2020.
• 8、 Warren,Smiles. "-". . p. 2207,2210. Retrieved 1931.
• 9、 Kashoulis, Annoula,Gilbert, Andrew,Ellis-Davies, Graham. "PHOTOCHEMICAL REACTIONS OF NAPHTHYL-VINYL NON-CONJUGATED BICHROMOPHORIC SYSTEMS". . p. 2905 - 2908. Retrieved 1984.
• 10、 Wessely,Grill. "-". . p. 282,286. Retrieved 1947.