mebudipine

Base Information

Chemical Name:mebudipine
CAS No.:103521-70-6
Molecular Formula:C₂₀H₂₄N₂O₆
Molecular Weight:388.42
Hs Code.:
Mol file:103521-70-6.mol

Synonyms:3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 1,1-dimethylethyl methylester (9CI); 3-tert-Butyl 5-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; BAY-n6391; Mebudipine

Suppliers and Price of mebudipine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of mebudipine

Chemical Property:

PSA：110.45000
LogP:4.19630

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of mebudipine

There total 4 articles about mebudipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1694-31-1
tert-butyl acetoacetate

: 99-61-6
3-nitro-benzaldehyde

: 21731-17-9
methyl 3-aminocrotonate

: 103521-70-6
(+/-)-Mebudipine

Guidance literature:: With piperidine; In ethanol; Reflux;
DOI:10.1021/jm1002827

Reference yield: 49.0%

: 14205-39-1
methyl (E)-3-aminocrotonate

: 103295-96-1
2-[(3-nitrophenyl)methylene]-3-oxobutanoic acid,1,1-dimethylethyl ester

: 103521-70-6
(+/-)-Mebudipine

Guidance literature:: In methanol; for 18h; Heating; protected from light;
DOI:10.1111/j.2042-7158.1997.tb06075.x

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 103521-70-6
(+/-)-Mebudipine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / acetic acid / piperidine / methanol / 4 h / 20 °C

2: 49 percent / methanol / 18 h / Heating; protected from light

With acetic acid; piperidine; In methanol; 1: Condensation / 2: Condensation;
DOI:10.1111/j.2042-7158.1997.tb06075.x