Thymidine, 3'-azido-3'-deoxy-, 5'-(4-chlorophenyl phosphonate)

Base Information

Chemical Name:Thymidine, 3'-azido-3'-deoxy-, 5'-(4-chlorophenyl phosphonate)
CAS No.:834918-68-2
Molecular Formula:C₁₆H₁₇ClN₅O₆P
Molecular Weight:441.768
Hs Code.:

Synonyms:

Suppliers and Price of Thymidine, 3'-azido-3'-deoxy-, 5'-(4-chlorophenyl phosphonate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Thymidine, 3'-azido-3'-deoxy-, 5'-(4-chlorophenyl phosphonate)

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of Thymidine, 3'-azido-3'-deoxy-, 5'-(4-chlorophenyl phosphonate)

There total 4 articles about Thymidine, 3'-azido-3'-deoxy-, 5'-(4-chlorophenyl phosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: C₁₀H₁₃N₅O₆P^(1-)

: 834918-68-2
C₁₆H₁₇ClN₅O₆P

Guidance literature:: With chlorophosphoric acid diphenyl ester; In pyridine; dichloromethane; for 2h;
DOI:10.1021/ol035166u

Reference yield:

: 15516-41-3
bis(4-chlorophenyl) phosphite

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 834918-68-2
C₁₆H₁₇ClN₅O₆P

Guidance literature:: With triethylamine; In tetrahydrofuran; at -5 ℃; for 20h;
DOI:10.1055/s-2004-834800

Reference yield:

: 834918-59-1
C₁₆H₁₈N₅O₆P

: 834918-68-2
C₁₆H₁₇ClN₅O₆P

Guidance literature:: Multi-step reaction with 3 steps

1: EtN(i-Pr)2 / CH₂Cl₂; pyridine / 0.08 h

2: Et₃N; H₂O / acetonitrile

3: diphenyl chlorophosphonate / CH₂Cl₂; pyridine / 2 h

With water; triethylamine; N-ethyl-N,N-diisopropylamine; chlorophosphoric acid diphenyl ester; In pyridine; dichloromethane; acetonitrile;
DOI:10.1021/ol035166u