L-Phenylalaninamide, L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]-

Base Information

Chemical Name:L-Phenylalaninamide, L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]-
CAS No.:835916-23-9
Molecular Formula:C48H46Cl2N6O7
Molecular Weight:889.835
Hs Code.:

L-Phenylalaninamide,
L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb
onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]-

Synonyms:

Suppliers and Price of L-Phenylalaninamide, L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Phenylalaninamide, L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of L-Phenylalaninamide, L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]-

There total 9 articles about L-Phenylalaninamide, L-tryptophyl-N-[(1R)-2-[[(2S)-3-carboxy-2-[[(9H-fluoren-9-ylmethoxy)carb onyl]amino]-1-oxopropyl]amino]-1-[(3,4-dichlorophenyl)methyl]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid tert-butyl ester

: 835916-23-9
N-[2-{2-[2-amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid

Guidance literature:: With etanedithiol; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm040832y

Reference yield:

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 835916-23-9
N-[2-{2-[2-amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; EDC*HCl / dimethylformamide / 30 h

1.2: dimethylformamide / 2 h / 20 °C

2.1: etanedithiol; CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

With etanedithiol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040832y

Reference yield:

: [1-aminomethyl-2-(3,4-dichloro-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 835916-23-9
N-[2-{2-[2-amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-(3,4-dichloro-phenyl)-propyl]-3-(9H-fluoren-9-ylmethoxycarbonylamino)-succinamic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N / tetrahydrofuran / 1 h / 20 °C

2.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

3.1: HOBt; EDC*HCl / dimethylformamide / 0.5 h / 0 °C

3.2: 1.13 g / Et₃N / dimethylformamide / 4 h / 20 °C

4.1: CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

5.1: HOBt; EDC*HCl; DIPEA / dimethylformamide / 2 h / 20 °C

6.1: Et₂NH / dimethylformamide / 2 h

7.1: HOBt; EDC*HCl / dimethylformamide / 30 h

7.2: dimethylformamide / 2 h / 20 °C

8.1: etanedithiol; CF₃CO₂H / CH₂Cl₂ / 0 - 20 °C

With etanedithiol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040832y