2-AZIDO-1-METHYLBENZIMIDAZOLE

Base Information

• Chemical Name: 2-AZIDO-1-METHYLBENZIMIDAZOLE
• CAS No.: 1516-73-0
• Molecular Formula: C8H7 N5
• Molecular Weight: 0
• Hs Code.: 2933990090
• Mol file: 1516-73-0.mol

Synonyms:Benzimidazole,2-azido-1-methyl- (6CI,7CI,8CI); 2-Azido-1-methylbenzimidazole

Chemical Property of 2-AZIDO-1-METHYLBENZIMIDAZOLE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 67.57000
• Density: g/cm³
• LogP: 1.96786

Purity/Quality:

99% ^*data from raw suppliers

2-Azido-1-methylbenzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AZIDO-1-METHYLBENZIMIDAZOLE

There total 6 articles about 2-AZIDO-1-METHYLBENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-2-hydrazinobenzimidazole (7022-37-9) → 2-azido-1-methyl-1H-benzo[d]imidazole (1516-73-0)

Guidance literature:

With hydrogenchloride; sodium nitrite; In ethanol; water; at 0 ℃;

DOI:10.1002/chem.201002491

Reference yield: 90.0%

1-Methylbenzimidazole (1632-83-3) → 2-azido-1-methyl-1H-benzo[d]imidazole (1516-73-0)

Guidance literature:

1-Methylbenzimidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With 4-toluenesulfonyl azide; In tetrahydrofuran; for 0.5h;

DOI:10.3987/COM-00-8952

Reference yield: 81.2%

2-bromo-1-methyl-1H-benzo[d]imidazole (49572-60-3) → 2-azido-1-methyl-1H-benzo[d]imidazole (1516-73-0)

Guidance literature:

With sodium azide; 15-crown-5; tributyltin chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; for 48h; Heating;

DOI:10.3987/COM-00-8952

upstream raw materials:

2-bromo-1-methyl-1H-benzo[d]imidazole

1-Methylbenzimidazole

2-chloro-1H-benzoimidazole

1-methyl-2-hydrazinobenzimidazole

Downstream raw materials:

2-Amino-1-methylbenzimidazole

tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate