5-FLUORO-1-METHYL-CYTOSINE

Base Information

• Chemical Name: 5-FLUORO-1-METHYL-CYTOSINE
• CAS No.: 155-15-7
• Molecular Formula: C₅H₆FN₃O
• Molecular Weight: 143.121
• Hs Code.: 2933599090
• Mol file: 155-15-7.mol

Synonyms:NSC 80844;Cytosine,5-fluoro-1-methyl- (7CI,8CI);

Chemical Property of 5-FLUORO-1-METHYL-CYTOSINE

Chemical Property:

• Vapor Pressure: 0.207mmHg at 25°C
• Refractive Index: 1.592
• Boiling Point: 209 °C at 760 mmHg
• Flash Point: 80.2 °C
• PSA: 58.69000
• Density: 1.49 g/cm³
• LogP: -0.17910

Purity/Quality:

98%min ^*data from raw suppliers

5-FLUORO-1-METHYL-CYTOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-1-METHYL-CYTOSINE

There total 9 articles about 5-FLUORO-1-METHYL-CYTOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-fluorocytosine (2022-85-7,130256-61-0) + methyl iodide (74-88-4) → 1-methyl-5-fluorocytosine (155-15-7)

Guidance literature:

With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; Heating;

Reference yield: 65.0%

1-methylcytosine (1122-47-0,176158-70-6) → Acetic acid 5,5-difluoro-6-imino-3-methyl-2-oxo-hexahydro-pyrimidin-4-yl ester (115923-85-8) + 1-methyl-5-fluorocytosine (155-15-7)

Guidance literature:

With acetyl hypofluorite; In tetradeuterioacetic acid;

Reference yield: 59.0%

Flucytosine (2022-85-7) + methyl iodide (74-88-4) → 5-Fluor-1-methyl-cytosin (155-15-7)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In dichloromethane; water; at 20 ℃; for 18h;

DOI:10.1039/c0nj00197j

upstream raw materials:

Methyl methanesulfonate

4-amino-5-fluoro-pyrimidin-2-ol

Flucytosine

methyl iodide

Refernces

• 1、 Moehlig, Aaron R.,Djernes, Katherine E.,Krishnan, V. Mahesh,Hooley, Richard J.. "Cytosine derivatives form hemiprotonated dimers in solution and the gas phase". . p. 2560 - 2563. Retrieved 2012.
• 2、 Greco, Elisabetta,Aliev, Abil E.,Lafitte, Valerie G. H.,Bala, Kason,Duncan, David,Pilon, Laura,Golding, Peter,Hailes, Helen C.. "Cytosine modules in quadruple hydrogen bonded arrays". experimental part. p. 2634 - 2642. Retrieved 2011/01/12.