2,5-Diazabicyclo[2.2.2]octane Dihydrochloride

Base Information

• Chemical Name: 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride
• CAS No.: 1192-92-3
• Molecular Formula: C6H12 N2 . 2 Cl H
• Molecular Weight: 185.097
• Hs Code.: 2933990090
• Mol file: 1192-92-3.mol

Synonyms:2,5-Diazabicyclo[2.2.2]octane,dihydrochloride (7CI,8CI,9CI); NSC 152740

Chemical Property of 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride

Chemical Property:

• Vapor Pressure: 0.402mmHg at 25°C
• Boiling Point: 196.3°Cat760mmHg
• Flash Point: 92.9°C
• PSA: 24.06000
• Density: 0.975g/cm³
• LogP: 1.16980

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Diazabicyclo[2.2.2]octaneDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride

There total 1 articles about 2,5-Diazabicyclo[2.2.2]octane Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C20H24N2*2ClH → 2,5-diazabicyclo[2.2.2]octane dihydrochloride (1192-92-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; for 16h;

Reference yield: 65.0%

C31H34N2O6S + 2,5-diazabicyclo[2.2.2]octane dihydrochloride (1192-92-3) → N-(cyclobutylsulfonyl)-8-cyclohexyl-1a-(2,5-diazabicyclo[2.2.2]oct-2-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 46.0%

t-butyl (2-(6-chloronicotinamido)phenyl)carbamate (623588-14-7) + 2,5-diazabicyclo[2.2.2]octane dihydrochloride (1192-92-3) → C23H29N5O3

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 90 ℃; for 48h;

Downstream raw materials:

tert‐butyl 2,5‐diazabicyclo[2.2.2]octane‐2‐carboxylate

tert-butyl (1aR,12bS)-8-cyclohexyl-1a-(2,5-diazabicyclo[2.2.2]oct-2-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

(1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-methyl-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid

Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-methyl-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Refernces