tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate

Base Information

Chemical Name:tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate
CAS No.:623588-14-7
Molecular Formula:C17H18ClN3O3
Molecular Weight:347.801
Hs Code.:
Mol file:623588-14-7.mol

Synonyms:tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate

Suppliers and Price of tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate

Chemical Property:

Boiling Point:396.2±37.0 °C(Predicted)
PKA:11.20±0.70(Predicted)
PSA：80.32000
Density:1.324±0.06 g/cm3(Predicted)
LogP:4.48030

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate

There total 6 articles about tert-Butyl (2-{[(6-Chloropyridin-3-yl)carbonyl] amino}phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 146651-75-4
tert–butyl (2–aminophenyl)carbamate

: 623588-14-7
t-butyl (2-(6-chloronicotinamido)phenyl)carbamate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield: 89.0%

: 58757-38-3
6-Chloronicotinoyl chloride

: 146651-75-4
tert–butyl (2–aminophenyl)carbamate

: 623588-14-7
t-butyl (2-(6-chloronicotinamido)phenyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/acsmedchemlett.8b00099

Reference yield:

: 875-51-4
4-Bromo-2-nitroaniline

: 623588-14-7
t-butyl (2-(6-chloronicotinamido)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; dmap / dichloromethane

2.1: potassium carbonate; dihydroxyborane / 1,4-dioxane; water / 0.5 h / Inert atmosphere

2.2: 20 h / 90 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

4.1: pyridine / 1.5 h

With pyridine; dmap; dihydroxyborane; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate;
DOI:10.1021/ml4004233