6-CHLORO-4-HYDROXY-2-METHYLQUINOLINE

Base Information

• Chemical Name: 6-CHLORO-4-HYDROXY-2-METHYLQUINOLINE
• CAS No.: 83842-54-0
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.633
• Mol file: 83842-54-0.mol

Synonyms:6-CHLORO-2-METHYLQUINOLIN-4-OL;6-Chlor-2-methyl-1H-chinolin-4-on;6-chloroactine;2-methyl-6-chloro-1H-quinolin-4-one;

Chemical Property of 6-CHLORO-4-HYDROXY-2-METHYLQUINOLINE

Chemical Property:

• PSA: 32.86000
• LogP: 2.48990

Purity/Quality:

6-Chloro-2-methylquinolin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-4-HYDROXY-2-METHYLQUINOLINE

There total 14 articles about 6-CHLORO-4-HYDROXY-2-METHYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 4-chloro-aniline (106-47-8) → HEI 713 (83842-54-0)

Guidance literature:

With NaHSO₄ on SiO₂ solid support; for 0.0833333h; Microwave irradiation; Neat (no solvent);

DOI:10.5012/jkcs.2010.54.6.723

Reference yield: 80.0%

5-Amino-8-chlor-2-methyl-4H-1-benzothiopyran-4-on-1,1-dioxid (88883-97-0) → HEI 713 (83842-54-0)

Guidance literature:

With ammonia; In ethanol; at 75 ℃; for 3h;

DOI:10.1002/ardp.19843170107

Reference yield: 77.0%

ethyl 3-((4-chlorophenyl)amino)but-2-enoate (41014-75-9) → HEI 713 (83842-54-0)

Guidance literature:

for 0.0666667h; microwave irradiation;

upstream raw materials:

formamide

5-Amino-8-chlor-2-methyl-4H-1-benzothiopyran-4-on-1,1-dioxid

carbon disulfide

malonic acid

Downstream raw materials:

C₁₈H₁₄ClN₃S

C₂₀H₁₈ClN₃S

C₁₈H₁₂Cl₂N₂OS

C₁₈H₁₃ClN₂S