3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

Base Information

Chemical Name:3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-
CAS No.:838819-70-8
Molecular Formula:C₂₆H₂₂FN₃O₃
Molecular Weight:443.477
Hs Code.:

Synonyms:YM-244769;N-(3-Amino-benzyl)-6-[4-(3-fluoro-benzyloxy)-phenoxy]-nicotinamide;

Suppliers and Price of 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

Chemical Property:

Boiling Point:679.4±55.0 °C(Predicted)
PSA：86.47000
Density:1.283±0.06 g/cm3(Predicted)
LogP:6.07630

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

There total 3 articles about 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 837424-32-5
6-[4-(3-fluoro-benzyloxy)-phenoxy]-N-(3-nitro-benzyl)-nicotinamide

: 838819-70-8
N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 100 ℃; for 1.5h;
DOI:10.1016/j.bmc.2004.10.047

Reference yield:

: 639091-33-1
6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinic acid

: 838819-70-8
N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 1-hydroxybenzotriazole; water-soluble carbodiimide *HCl / tetrahydrofuran / 20 °C

2: Fe; NH₄Cl / ethanol; H₂O / 1.5 h / 100 °C

With water-soluble carbodiimide *HCl; iron; ammonium chloride; benzotriazol-1-ol; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2004.10.047

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 838819-70-8
N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy}nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 1-hydroxybenzotriazole; water-soluble carbodiimide *HCl / tetrahydrofuran / 20 °C

2: Fe; NH₄Cl / ethanol; H₂O / 1.5 h / 100 °C

With water-soluble carbodiimide *HCl; iron; ammonium chloride; benzotriazol-1-ol; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2004.10.047